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Author (up) Sorgjerd, E.P.; Thorsby, P.M.; Torjesen, P.A.; Skorpen, F.; Kvaloy, K.; Grill, V.   
  Title Presence of anti-GAD in a non-diabetic population of adults; time dynamics and clinical influence: results from the HUNT study Type Journal Article
  Year 2015 Publication BMJ Open Diabetes Res Care Abbreviated Journal BMJ open diabetes research & care  
  Volume 3 Issue 1 Pages e000076  
  Keywords HUNT2; HUNT3  
  Abstract BACKGROUND: It is well known that anti-GAD (glutamic acid decarboxylase) serves as a marker for development of autoimmune diabetes in adults. On the other hand, the clinical implications of anti-GAD positivity in persistently non-diabetic (PND) adults are poorly elucidated. Our aim was to establish the frequency of anti-GAD in PNDs in an all-population-based cohort from the Nord-Trondelag health study (HUNT) and to prospectively test for associations with glucose tolerance and thyroid autoimmunity. METHODS: We formed a primary study population (4496 individuals), selected randomly from the age group 20-90 years (50% men/women), who were non-diabetic both at HUNT2 (1995-1997) and HUNT3 (2006-2008). Anti-GAD-positive individuals at HUNT2, together with anti-GAD-negative individuals aged 20-29 years, were retested for anti-GAD positivity at HUNT3. A secondary study population consisted of individuals with type 2 diabetes (T2D, n=349) at HUNT3 who developed diabetes between HUNT2 and HUNT3. RESULTS: The frequency of anti-GAD positivity in PND was 1.7% (n=76) at HUNT2. Positivity did not associate with gender, family history of diabetes, or glucose levels, but was associated with thyroid-associated autoimmunity (increased frequency of positivity for anti-TPO (thyroid peroxidase), p  
  Corporate Author Thesis  
  Publisher Place of Publication Department of Public Health and General Practice, Faculty of Medicine , HUNT Research Centre, The No Editor  
  Language Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN ISBN Medium  
  Area Expedition Conference  
  Notes Approved no  
  Call Number HUNT @ maria.stuifbergen @ Sorgjerd2015 Serial 1862  
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