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Author (up) Tang, C.S.; Zhang, H.; Cheung, C.Y.; Xu, M.; Ho, J.C.; Zhou, W.; Cherny, S.S.; Zhang, Y.; Holmen, O.; Au, K.W.; Yu, H.; Xu, L.; Jia, J.; Porsch, R.M.; Sun, L.; Xu, W.; Zheng, H.; Wong, L.Y.; Mu, Y.; Dou, J.; Fong, C.H.; Wang, S.; Hong, X.; Dong, L.; Liao, Y.; Wang, J.; Lam, L.S.; Su, X.; Yan, H.; Yang, M.L.; Chen, J.; Siu, C.W.; Xie, G.; Woo, Y.C.; Wu, Y.; Tan, K.C.; Hveem, K.; Cheung, B.M.; Zollner, S.; Xu, A.; Eugene Chen, Y.; Jiang, C.Q.; Lam, T.H.; Ganesh, S.K.; Huo, Y.; Sham, P.C.; Lam, K.S.; Willer, C.J.; Tse, H.F.; Gao, W.   
  Title Exome-wide association analysis reveals novel coding sequence variants associated with lipid traits in Chinese Type Journal Article
  Year 2015 Publication Nat Commun Abbreviated Journal Nature communications  
  Volume 6 Issue Pages 10206  
  Keywords Asian Continental Ancestry Group/*genetics; Cholesterol, HDL/metabolism; Cholesterol, LDL/metabolism; Exome/*genetics; *Genetic Variation; Genotype; Humans; Lipid Metabolism/*genetics; Triglycerides/metabolism  
  Abstract Blood lipids are important risk factors for coronary artery disease (CAD). Here we perform an exome-wide association study by genotyping 12,685 Chinese, using a custom Illumina HumanExome BeadChip, to identify additional loci influencing lipid levels. Single-variant association analysis on 65,671 single nucleotide polymorphisms reveals 19 loci associated with lipids at exome-wide significance (P  
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  Corporate Author Thesis  
  Publisher Place of Publication Department of Psychiatry, the University of Hong Kong, Hong Kong, China.Department of Internal Medic Editor  
  Language Summary Language Original Title  
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  Notes Approved no  
  Call Number HUNT @ maria.stuifbergen @ Tang2015 Serial 1866  
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