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Author (up) von Krogh, A.S.; Kremer Hovinga, J.A.; Romundstad, P.R.; Roten, L.T.; Lammle, B.; Waage, A.; Quist-Paulsen, P. url  doi
  Title ADAMTS13 gene variants and function in women with preeclampsia: a population- based nested case- control study from the HUNT Study Type Journal Article
  Year 2015 Publication Thromb Res Abbreviated Journal Thrombosis research  
  Volume 136 Issue 2 Pages 282-288  
  Keywords HUNT2; ADAM Proteins/*genetics; Adult; Case-Control Studies; Female; Genetic Variation/*genetics; Genotype; Humans; Middle Aged; Mutation; Pregnancy  
  Abstract INTRODUCTION: Known genetic variants with reference to preeclampsia only explain a proportion of the heritable contribution to the development of this condition. The association between preeclampsia and the risk of cardiovascular disease later in life has encouraged the study of genetic variants important in thrombosis and vascular inflammation also in relation to preeclampsia. The von Willebrand factor-cleaving protease, ADAMTS13, plays an important role in micro vascular thrombosis, and partial deficiencies of this enzyme have been observed in association with cardiovascular disease and preeclampsia. However, it remains unknown whether decreased ADAMTS13 levels represent a cause or an effect of the event in placental and cardiovascular disease. METHODS: We studied the distribution of three functional genetic variants of ADAMTS13, c.1852C>G (rs28647808), c.4143_4144dupA (rs387906343), and c.3178C>T (rs142572218) in women with preeclampsia and their controls in a nested case-control study from the second Nord-Trondelag Health Study (HUNT2). We also studied the association between ADAMTS13 activity and preeclampsia, in serum samples procured unrelated in time of the preeclamptic pregnancy. RESULTS: No differences were observed in genotype, allele or haplotype frequencies of the different ADAMTS13 variants when comparing cases and controls, and no association to preeclampsia was found with lower levels of ADAMTS13 activity. CONCLUSION: Our findings indicate that ADAMTS13 variants and ADAMTS13 activity do not contribute to an increased risk of preeclampsia in the general population.  
  Address  
  Corporate Author Thesis  
  Publisher Place of Publication Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology Editor  
  Language Summary Language Original Title  
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  Series Volume Series Issue Edition  
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  Area Expedition Conference  
  Notes von Krogh, Anne-SophieKremer Hovinga, Johanna ARomundstad, Pal RRoten, Linda TLammle, BernhardWaage, AndersQuist-Paulsen, PetterengResearch Support, Non-U.S. Gov't2015/07/04 06:00Thromb Res. 2015 Aug;136(2):282-8. doi: 10.1016/j.thromres.2015.06.022. Epub 2015 Jun 18. Approved no  
  Call Number HUNT @ maria.stuifbergen @ vonKrogh2015 Serial 1872  
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