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Author |
Gemes, K.; Malmo, V.; Laugsand, L.E.; Loennechen, J.P.; Ellekjaer, H.; Laszlo, K.D.; Ahnve, S.; Vatten, L.J.; Mukamal, K.J.; Janszky, I. |
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Title |
Does Moderate Drinking Increase the Risk of Atrial Fibrillation? The Norwegian HUNT (Nord-Trondelag Health) Study |
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Journal Article |
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Year |
2017 |
Publication |
Journal of the American Heart Association |
Abbreviated Journal |
J Am Heart Assoc |
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Volume |
6 |
Issue |
10 |
Pages |
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Keywords |
Hunt; alcohol; atrial fibrillation; cohort study; epidemiology; moderate alcohol |
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Abstract |
BACKGROUND: Compelling evidence suggests that excessive alcohol consumption increases the risk of atrial fibrillation (AF), but the effect of light-moderate alcohol consumption is less certain. We investigated the association between alcohol consumption within recommended limits and AF risk in a light-drinking population. METHODS AND RESULTS: Among 47 002 participants with information on alcohol consumption in a population-based cohort study in Norway, conducted from October 2006 to June 2008, 1697 validated AF diagnoses were registered during the 8 years of follow-up. We used Cox proportional hazard models with fractional polynomials to analyze the association between alcohol intake and AF. Population attributable risk for drinking within the recommended limit (ie, at most 1 drink per day for women and 2 drinks per day for men without risky drinking) compared with nondrinking was also calculated. The average alcohol intake was 3.8+/-4.8 g/d. The adjusted hazard ratio for AF was 1.38 (95% confidence interval, 1.06-1.80) when we compared participants consuming >7 drinks per week with abstainers. When we modeled the quantity of alcohol intake as a continuous variable, the risk increased in a curvilinear manner. It was higher with heavier alcohol intake, but there was virtually no association at <1 drink per day for women and <2 drinks per day for men in the absence of risky drinking. The population attributable risk among nonrisky drinkers was 0.07% (95% confidence interval, -0.01% to 0.13%). CONCLUSIONS: Although alcohol consumption was associated with a curvilinearly increasing risk of AF in general, the attributable risk of alcohol consumption within recommended limits among participants without binge or problem drinking was negligible in this population. |
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Regional Center for Health Care Improvement, St Olav's Hospital, Trondheim, Norway |
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Language |
English |
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Original Title |
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ISSN |
2047-9980 |
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Conference  |
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Notes |
PMID:29054845; PMCID:PMC5721892 |
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no |
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Call Number |
HUNT @ maria.stuifbergen @ |
Serial |
1901 |
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