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Author Naicker, K.; Johnson, J.A.; Skogen, J.C.; Manuel, D.; Overland, S.; Sivertsen, B.; Colman, I.
Title Type 2 Diabetes and Comorbid Symptoms of Depression and Anxiety: Longitudinal Associations With Mortality Risk Type Journal Article
Year 2017 Publication Diabetes Care Abbreviated Journal Diabetes Care
Volume 40 Issue 3 Pages 352-358
Keywords Adult; Aged; Aged, 80 and over; Anxiety/*complications; Comorbidity; Depression/*complications; Diabetes Mellitus, Type 2/*complications; Female; Follow-Up Studies; Humans; Male; Middle Aged; Norway/epidemiology; Proportional Hazards Models; Risk Factors; Socioeconomic Factors; Surveys and Questionnaires; Young Adult
Abstract OBJECTIVE: Depression is strongly linked to increased mortality in individuals with type 2 diabetes. Despite high rates of co-occurring anxiety and depression, the risk of death associated with comorbid anxiety in individuals with type 2 diabetes is poorly understood. This study documented the excess mortality risk associated with symptoms of depression and/or anxiety comorbid with type 2 diabetes. RESEARCH DESIGN AND METHODS: Using data for 64,177 Norwegian adults from the second wave of the Nord-Trondelag Health Study (HUNT2), with linkage to the Norwegian Causes of Death Registry, we assessed all-cause mortality from survey participation in 1995 through to 2013. We used Cox proportional hazards models to examine mortality risk over 18 years associated with type 2 diabetes status and the presence of comorbid affective symptoms at baseline. RESULTS: Three clear patterns emerged from our findings. First, mortality risk in individuals with diabetes increased in the presence of depression or anxiety, or both. Second, mortality risk was lowest for symptoms of anxiety, higher for comorbid depression-anxiety, and highest for depression. Lastly, excess mortality risk associated with depression and anxiety was observed in men with diabetes but not in women. The highest risk of death was observed in men with diabetes and symptoms of depression only (hazard ratio 3.47, 95% CI 1.96, 6.14). CONCLUSIONS: This study provides evidence that symptoms of anxiety affect mortality risk in individuals with type 2 diabetes independently of symptoms of depression, in addition to attenuating the relationship between depressive symptoms and mortality in these individuals.
Address School of Public Health and Preventive Medicine, University of Ottawa, Ontario, Canada icolman@uottawa.ca
Corporate Author Thesis
Publisher Place of Publication Editor
Language English Summary Language Original Title
Series Editor Series Title Abbreviated Series Title
Series Volume Series Issue Edition
ISSN 0149-5992 ISBN Medium
Area Expedition Conference
Notes PMID:28077458 Approved (up) no
Call Number HUNT @ maria.stuifbergen @ Serial 1961
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