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Author |
Osthus, I.B.O.; Lydersen, S.; Dalen, H.; Nauman, J.; Wisloff, U. |
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Title |
Association of Telomere Length With Myocardial Infarction: A Prospective Cohort From the Population Based HUNT 2 Study |
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Journal Article |
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Year |
2017 |
Publication |
Progress in Cardiovascular Diseases |
Abbreviated Journal |
Prog Cardiovasc Dis |
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Volume |
59 |
Issue |
6 |
Pages |
649-655 |
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Keywords |
Age Factors; Aged; Aged, 80 and over; Female; Genetic Markers; Humans; Incidence; Linear Models; Male; Multivariate Analysis; Myocardial Infarction/diagnosis/epidemiology/*genetics; Norway/epidemiology; Polymerase Chain Reaction; Predictive Value of Tests; Prognosis; Proportional Hazards Models; Prospective Studies; Risk Factors; Sex Factors; Telomere/*genetics; *Telomere Homeostasis; Time Factors; Cardiovascular diseases; Myocardial infarction; Prevention; Risk factors; Telomeres |
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Abstract |
As possible markers of biological age, telomere length (TL) has been associated with age-related diseases such as myocardial infarction (MI) with conflicting findings. We sought to assess the relationship between TL and risk of future MI in 915 healthy participants (51.7% women) 65 years or older from a population-based prospective cohort (the HUNT 2 study, Norway). Mean TL was measured by quantitative PCR expressed as relative T (telomere repeat copy number) to S (single copy gene number) ratio, and log-transformed. During a mean follow up of 13.0 (SD, 3.2) years and 11,923 person-years, 82 participants were diagnosed with MI. We used Cox proportional hazard regressions to estimate hazard ratios (HR) and 95% confidence interval (CI). Relative TL was associated with age in women (P=0.01), but not in men (P=0.43). Using relative TL as a continuous variable, we observed a higher risk of MI in participants with longer telomeres with HRs of 2.46 (95% CI; 1.13 to 4.54) in men, and 2.93 (95% CI; 1.41 to 6.10) in women. Each 1-SD change in relative TL was associated with an HR of 1.54 (95% CI; 1.15 to 2.06) and 1.67 (95% CI; 1.18 to 2.37) in men and women, respectively. Compared with the bottom tertile of relative TL, HR of incident MI in top tertile was 2.71 (95% CI; 1.25 to 5.89) in men, and 3.65 (95% CI; 1.35 to 9.90) in women. Longer telomeres in healthy participants 65 years or older are associated with a high risk of incident MI. Future large scale prospective studies are needed to confirm these findings and explore the potential association between TL and MI. |
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Address |
K. G. Jebsen Center of Exercise in Medicine at the Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway; School of Human Movement & Nutrition Sciences, University of Queensland, Australia |
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English |
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0033-0620 |
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Notes |
PMID:28442329 |
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no |
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Call Number |
HUNT @ maria.stuifbergen @ |
Serial |
1968 |
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