| |
Record |
Links |
|
Author  |
Ueland, T.; Laugsand, L.E.; Vatten, L.J.; Janszky, I.; Platou, C.; Michelsen, A.E.; Damas, J.K.; Aukrust, P.; Asvold, B.O. |
|
| |
Title |
Monocyte/macrophage and T cell activation markers are not independently associated with MI risk in healthy individuals – results from the HUNT Study |
Type |
Journal Article |
| |
Year |
2017 |
Publication |
International Journal of Cardiology |
Abbreviated Journal |
Int J Cardiol |
|
| |
Volume |
243 |
Issue |
|
Pages |
502-504 |
|
| |
Keywords |
Leukocyte markers; Myocardial infarction |
|
| |
Abstract |
BACKGROUND: We hypothesized that circulating markers reflecting monocyte/macrophage and T cell activation are associated with increased risk of myocardial infarction (MI) in apparently healthy individuals. METHODS: Serum monocyte/macrophage and T cell activation markers soluble (s) CD163, sCD14, Gal3BP, sCD25 and sCD166 were analyzed by enzyme-immunoassay in a case-control study nested within the population-based HUNT2 cohort in Norway. Among 58,761 apparently healthy men and women followed a median 11.3years, 1587 incident MI cases were registered, and compared to 3959 age- and sex-matched controls. RESULTS: Higher serum sCD163 (Q4 vs. Q1 OR: 1.27, P-trend 0.002), sCD14 (Q4 vs. Q1 OR: 1.38, P-trend<0.001), and especially sCD25 (Q4 vs. Q1 OR: 1.45, P-trend<0.001), were associated with increased MI risk in the age-and sex adjusted models. However, after additional adjustment for cardiovascular risk factors these associations were strongly attenuated (Q4 vs Q1 ORs between 1.02 and 1.12, P-trends between 0.30 and 0.58). CONCLUSIONS: sCD163, sCD14 and sCD25 may reflect leukocyte activation and inflammatory mechanisms related to atherogenesis, but do not predict MI risk above and beyond conventional cardiovascular risk factors. |
|
| |
Address |
Department of Public Health, NTNU, Norwegian University of Science and Technology, Trondheim, Norway; Department of Endocrinology, St. Olavs Hospital, Trondheim, Norway |
|
| |
Corporate Author |
|
Thesis |
|
|
| |
Publisher |
|
Place of Publication |
|
Editor |
|
|
| |
Language |
English |
Summary Language |
|
Original Title |
|
|
| |
Series Editor |
|
Series Title |
|
Abbreviated Series Title |
|
|
| |
Series Volume |
|
Series Issue |
|
Edition |
|
|
| |
ISSN |
0167-5273 |
ISBN |
|
Medium |
|
|
| |
Area |
|
Expedition |
|
Conference |
|
|
| |
Notes |
PMID:28615143 |
Approved |
no |
|
| |
Call Number |
HUNT @ maria.stuifbergen @ |
Serial |
2016 |
|
| Permanent link to this record |
