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Author (up) Brumpton, B.M.; Langhammer, A.; Henriksen, A.H.; Romundstad, P.R.; Chen, Y.; Camargo, C.A.J.; Mai, X.-M. url  doi
  Title Serum 25-hydroxyvitamin D, vitamin D supplement and asthma control: The HUNT study Type Journal Article
  Year 2018 Publication Respiratory Medicine Abbreviated Journal Respir Med  
  Volume 136 Issue Pages 65-70  
  Keywords Adult; Aged; Asthma/*prevention & control; Cross-Sectional Studies; Dietary Supplements; Female; Humans; Male; Middle Aged; Prospective Studies; Risk Factors; Vitamin D/administration & dosage/*analogs & derivatives/blood; Vitamin D Deficiency/*complications/drug therapy; Vitamins/*administration & dosage; Young Adult; *Asthma; *Epidemiology; *Vitamin-D  
  Abstract Few studies have investigated the association between serum 25-hydroxyvitamin D (25[OH]D), vitamin D supplement and asthma control among adults. We aimed to examine whether low levels of serum 25(OH)D or not taking vitamin D supplement were associated with an increased risk of poorly controlled asthma among Norwegian adults with asthma. We used a definition of asthma control adapted from the Global Initiative for Asthma. We first examined cross-sectional associations between serum 25(OH)D (n=806) or vitamin D supplement (n=1179) and poorly controlled asthma. Next, among those with well controlled asthma at baseline, we examined prospective associations between serum 25(OH)D (n=147) or vitamin D supplement (n=208) and poorly controlled asthma at follow-up, approximately 11 years later. We estimated risk ratios (RR) and 95% confidence intervals (CI) with Poisson regression. The adjusted RR for poorly controlled asthma was 1.00 (95% CI, 0.89-1.13) for adults with serum 25(OH)D<50nmol/L in cross-sectional and 1.50 (95% CI, 0.46-4.95) in prospective analyses. The adjusted RR for poorly controlled asthma was 1.17 (95% CI 1.00-1.37) for non-users of vitamin D supplement in cross-sectional and 1.66 (95% CI 0.49-5.67) in prospective analyses. Our study did not show strong evidence that among adults with asthma, having a low serum 25(OH)D or being a non-user of vitamin D supplement was associated with an increased risk of poorly controlled asthma. Some point estimates indicated an increased risk, however our estimates were generally imprecise and further evidence is needed.  
  Address Department of Public Health and General Practice, Faculty of Medicine, NTNU, Norwegian University of Science and Technology, Trondheim, Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0954-6111 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29501248 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 2075  
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