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Author (up) Gabin, J.M.; Saltvedt, I.; Tambs, K.; Holmen, J. url  doi
  Title The association of high sensitivity C-reactive protein and incident Alzheimer disease in patients 60 years and older: The HUNT study, Norway Type Journal Article
  Year 2018 Publication Immunity & Ageing : I & A Abbreviated Journal Immun Ageing  
  Volume 15 Issue Pages 4  
  Keywords Alzheimer disease; Epidemiology; High sensitivity C-reactive protein; Low-grade inflammation  
  Abstract Background: With ageing, long-standing inflammation can be destructive, contributing to development of several disorders, among these Alzheimer's disease (AD). C-reactive protein (CRP) is a relatively stable peripheral inflammatory marker, but in previous studies the association between highly sensitive CRP (hsCRP) and AD have shown inconsistent results. This study examines the association between AD and hsCRP in blood samples taken up to 15 years prior to the diagnoses of 52 persons with AD amongst a total of 2150 persons >/=60 years of age. Results: Data from Norway's Nord-Trondelag Health Study (HUNT 2) and the Health and Memory Study (HMS) were linked. The participants had an average age of 73 years, and diagnosed with AD up to 15 years [mean 8.0 (+/-3.9)] following hsCRP measurement. Logistic regression models showed an adverse association between hsCRP and AD in participants aged 60-70.5 (odds ratio: 2.37, 95% CI: 1.01-5.58). Conversely, in participants aged 70.6-94, there was an inverse association between hsCRP and AD (odds ratio: 0.39, 95% CI: 0.19-0.84). When applying multivariate models the findings were significant in individuals diagnosed 0.4-7 years after the hsCRP was measured; and attenuated when AD was diagnosed more than seven years following hsCRP measurement. Conclusions: Our study is in line with previous studies indicating a shift in the association between hsCRP and AD by age: in adults (60-70.5 years) there is an adverse association, while in seniors (>70.6 years) there is an inverse association. If our findings can be replicated, a focus on why a more active peripheral immune response may have a protective role in individuals >/=70 years should be further examined.  
  Address 1HUNT Research Centre, Department of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Forskningsveien 2, 7600 Levanger, Norway.0000 0001 1516 2393grid.5947.f  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1742-4933 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29387136; PMCID:PMC5776764 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 2083  
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