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Author (up) Haug, E.B.; Horn, J.; Markovitz, A.R.; Fraser, A.; Vatten, L.J.; Macdonald-Wallis, C.; Tilling, K.; Romundstad, P.R.; Rich-Edwards, J.W.; Asvold, B.O. url  doi
  Title Life Course Trajectories of Cardiovascular Risk Factors in Women With and Without Hypertensive Disorders in First Pregnancy: The HUNT Study in Norway Type Journal Article
  Year 2018 Publication Journal of the American Heart Association Abbreviated Journal J Am Heart Assoc  
  Volume 7 Issue 15 Pages e009250  
  Keywords cardiovascular risk factors; epidemiology; hypertensive disorders of pregnancy; life course  
  Abstract Background Women with hypertensive pregnancy disorders have adverse levels of cardiovascular risk factors. It is unclear how this adverse risk factor profile evolves during adult life. We compared life course trajectories of cardiovascular risk factors in women with preeclampsia or gestational hypertension in their first pregnancy to normotensive women. Methods and Results We linked information on cardiovascular risk factors from the population-based HUNT (Nord-Trondelag Health Study) surveys with pregnancy information from the Medical Birth Registry of Norway. Trajectories of cardiovascular risk factors were constructed for 22 308 women with a normotensive first pregnancy; 1092 with preeclampsia, and 478 with gestational hypertension in first pregnancy. Already before first pregnancy, women with preeclampsia in their first pregnancy had higher measures of adiposity, blood pressure, heart rate, and serum lipids and glucose compared with women with a normotensive first pregnancy. After first pregnancy, there was a parallel development in cardiovascular risk factor levels, but women with a normotensive first pregnancy had a time lag of >10 years compared with the preeclampsia group. There were no clear differences in risk factor trajectories between women with gestational hypertension and women with preeclampsia. Conclusions Women with hypertensive pregnancy disorders in their first pregnancy had an adverse cardiovascular risk factor profile before pregnancy compared with normotensive women, and the differences persisted beyond 50 years of age. Hypertensive disorders in pregnancy signal long-term increases in modifiable cardiovascular risk factors, and may be used to identify women who would benefit from early prevention strategies.  
  Address 6 Department of Endocrinology St. Olavs Hospital Trondheim University Hospital Trondheim Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 2047-9980 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30371249; PMCID:PMC6201453 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 2092  
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