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Author (up) Hjort, R.; Ahlqvist, E.; Carlsson, P.-O.; Grill, V.; Groop, L.; Martinell, M.; Rasouli, B.; Rosengren, A.; Tuomi, T.; Asvold, B.O.; Carlsson, S. url  doi
  Title Overweight, obesity and the risk of LADA: results from a Swedish case-control study and the Norwegian HUNT Study Type Journal Article
  Year 2018 Publication Diabetologia Abbreviated Journal Diabetologia  
  Volume 61 Issue 6 Pages 1333-1343  
  Keywords Adult; Aged; Autoantibodies/blood; Body Mass Index; Case-Control Studies; Diabetes Mellitus, Type 2/*epidemiology; Female; Humans; Insulin Resistance; Insulin-Secreting Cells/metabolism; Latent Autoimmune Diabetes in Adults/*complications/*diagnosis/*epidemiology; Male; Middle Aged; Norway/epidemiology; Obesity/*complications/epidemiology; Odds Ratio; Overweight/*complications/epidemiology; Prospective Studies; Risk Factors; Sweden; Young Adult; *Andis; *ANDiU; *Body mass index; *Case-control study; *Estrid; *HUNT Study; *Lada; *Latent autoimmune diabetes in adults; *Prospective study; *Type 2 diabetes  
  Abstract AIMS/HYPOTHESIS: Excessive weight is a risk factor for type 2 diabetes, but its role in the promotion of autoimmune diabetes is not clear. We investigated the risk of latent autoimmune diabetes in adults (LADA) in relation to overweight/obesity in two large population-based studies. METHODS: Analyses were based on incident cases of LADA (n = 425) and type 2 diabetes (n = 1420), and 1704 randomly selected control participants from a Swedish case-control study and prospective data from the Norwegian HUNT Study including 147 people with LADA and 1,012,957 person-years of follow-up (1984-2008). We present adjusted ORs and HRs with 95% CI. RESULTS: In the Swedish data, obesity was associated with an increased risk of LADA (OR 2.93, 95% CI 2.17, 3.97), which was even stronger for type 2 diabetes (OR 18.88, 95% CI 14.29, 24.94). The association was stronger in LADA with low GAD antibody (GADA; <median) (OR 4.25; 95% CI 2.76, 6.52) but present also in LADA with high GADA (OR 2.14; 95% CI 1.42, 3.24). In the Swedish data, obese vs normal weight LADA patients had lower GADA levels, better beta cell function, and were more likely to have low-risk HLA-genotypes. The combination of overweight and family history of diabetes (FHD) conferred an OR of 4.57 (95% CI 3.27, 6.39) for LADA and 24.51 (95% CI 17.82, 33.71) for type 2 diabetes. Prospective data from HUNT indicated even stronger associations; HR for LADA was 6.07 (95% CI 3.76, 9.78) for obesity and 7.45 (95% CI 4.02, 13.82) for overweight and FHD. CONCLUSIONS/INTERPRETATION: Overweight/obesity is associated with increased risk of LADA, particularly when in combination with FHD. These findings support the hypothesis that, even in the presence of autoimmunity, factors linked to insulin resistance, such as excessive weight, could promote onset of diabetes.  
  Address Unit of Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Box 210, 171 77, Stockholm, Sweden  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0012-186X ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29589073 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 2098  
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