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Author (up) Larose, T.L.; Guida, F.; Fanidi, A.; Langhammer, A.; Kveem, K.; Stevens, V.L.; Jacobs, E.J.; Smith-Warner, S.A.; Giovannucci, E.; Albanes, D.; Weinstein, S.J.; Freedman, N.D.; Prentice, R.; Pettinger, M.; Thomson, C.A.; Cai, Q.; Wu, J.; Blot, W.J.; Arslan, A.A.; Zeleniuch-Jacquotte, A.; Le Marchand, L.; Wilkens, L.R.; Haiman, C.A.; Zhang, X.; Stampfer, M.J.; Hodge, A.M.; Giles, G.G.; Severi, G.; Johansson, M.; Grankvist, K.; Wang, R.; Yuan, J.-M.; Gao, Y.-T.; Koh, W.-P.; Shu, X.-O.; Zheng, W.; Xiang, Y.-B.; Li, H.; Lan, Q.; Visvanathan, K.; Hoffman Bolton, J.; Ueland, P.M.; Midttun, O.; Caporaso, N.; Purdue, M.; Sesso, H.D.; Buring, J.E.; Lee, I.-M.; Gaziano, J.M.; Manjer, J.; Brunnstrom, H.; Brennan, P.; Johansson, M. url  doi
  Title Circulating cotinine concentrations and lung cancer risk in the Lung Cancer Cohort Consortium (LC3) Type Journal Article
  Year 2018 Publication International Journal of Epidemiology Abbreviated Journal Int J Epidemiol  
  Volume 47 Issue 6 Pages 1760-1771  
  Keywords  
  Abstract Background: Self-reported smoking is the principal measure used to assess lung cancer risk in epidemiological studies. We evaluated if circulating cotinine-a nicotine metabolite and biomarker of recent tobacco exposure-provides additional information on lung cancer risk. Methods: The study was conducted in the Lung Cancer Cohort Consortium (LC3) involving 20 prospective cohort studies. Pre-diagnostic serum cotinine concentrations were measured in one laboratory on 5364 lung cancer cases and 5364 individually matched controls. We used conditional logistic regression to evaluate the association between circulating cotinine and lung cancer, and assessed if cotinine provided additional risk-discriminative information compared with self-reported smoking (smoking status, smoking intensity, smoking duration), using receiver-operating characteristic (ROC) curve analysis. Results: We observed a strong positive association between cotinine and lung cancer risk for current smokers [odds ratio (OR ) per 500 nmol/L increase in cotinine (OR500): 1.39, 95% confidence interval (CI): 1.32-1.47]. Cotinine concentrations consistent with active smoking (>/=115 nmol/L) were common in former smokers (cases: 14.6%; controls: 9.2%) and rare in never smokers (cases: 2.7%; controls: 0.8%). Former and never smokers with cotinine concentrations indicative of active smoking (>/=115 nmol/L) also showed increased lung cancer risk. For current smokers, the risk-discriminative performance of cotinine combined with self-reported smoking (AUCintegrated: 0.69, 95% CI: 0.68-0.71) yielded a small improvement over self-reported smoking alone (AUCsmoke: 0.66, 95% CI: 0.64-0.68) (P = 1.5x10-9). Conclusions: Circulating cotinine concentrations are consistently associated with lung cancer risk for current smokers and provide additional risk-discriminative information compared with self-report smoking alone.  
  Address Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0300-5771 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29901778; PMCID:PMC6280953 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 2126  
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