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Author (up) Markovitz, A.R.; Haug, E.B.; Horn, J.; Fraser, A.; Macdonald-Wallis, C.; Tilling, K.; Rimm, E.B.; Missmer, S.A.; Williams, P.L.; Romundstad, P.R.; Asvold, B.O.; Rich-Edwards, J.W. url  doi
  Title Does pregnancy alter life-course lipid trajectories? Evidence from the HUNT Study in Norway Type Journal Article
  Year 2018 Publication Journal of Lipid Research Abbreviated Journal J Lipid Res  
  Volume 59 Issue 12 Pages 2403-2412  
  Keywords Nord-Trondelag Health Study; cholesterol; epidemiology; high density lipoprotein; mixed model; parity; spline; triglycerides  
  Abstract We examined the association between pregnancy and life-course lipid trajectories. Linked data from the Nord-Trondelag Health Study and the Medical Birth Registry of Norway yielded 19,987 parous and 1,625 nulliparous women. Using mixed-effects spline models, we estimated differences in nonfasting lipid levels from before to after first birth in parous women and between parous and nulliparous women. HDL cholesterol (HDL-C) dropped by -4.2 mg/dl (95% CI: -5.0, -3.3) from before to after first birth in adjusted models, a 7% change, and the total cholesterol (TC) to HDL-C ratio increased by 0.18 (95% CI: 0.11, 0.25), with no change in non-HDL-C or triglycerides. Changes in HDL-C and the TC/HDL-C ratio associated with pregnancy persisted for decades, leading to altered life-course lipid trajectories. For example, parous women had a lower HDL-C than nulliparous women at the age of 50 years (-1.4 mg/dl; 95% CI: -2.3, -0.4). Adverse changes in lipids were greatest after first birth, with small changes after subsequent births, and were larger in women who did not breastfeed. Findings suggest that pregnancy is associated with long-lasting adverse changes in HDL-C, potentially setting parous women on a more atherogenic trajectory than prior to pregnancy.  
  Address Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0022-2275 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30314998; PMCID:PMC6277164 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 2132  
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