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Author (up) Moholdt, T.; Lavie, C.J.; Nauman, J. url  doi
  Title Sustained Physical Activity, Not Weight Loss, Associated With Improved Survival in Coronary Heart Disease Type Journal Article
  Year 2018 Publication Journal of the American College of Cardiology Abbreviated Journal J Am Coll Cardiol  
  Volume 71 Issue 10 Pages 1094-1101  
  Keywords Hunt; body mass index; exercise; mortality; myocardial infarction; obesity paradox  
  Abstract BACKGROUND: Individuals with coronary heart disease (CHD) are recommended to be physically active and to maintain a healthy weight. There is a lack of data on how long-term changes in body mass index (BMI) and physical activity (PA) relate to mortality in this population. OBJECTIVES: This study sought to determine the associations among changes in BMI, PA, and mortality in individuals with CHD. METHODS: The authors studied 3,307 individuals (1,038 women) with CHD from the HUNT (Nord-Trondelag Health Study) with examinations in 1985, 1996, and 2007, followed until the end of 2014. They calculated the hazard ratio (HR) for all-cause and cardiovascular disease (CVD) mortality according to changes in BMI and PA, and estimated using Cox proportional hazards regression models adjusted for age, smoking, blood pressure, diabetes, alcohol, and self-reported health. RESULTS: There were 1,493 deaths during 30 years of follow-up (55% from CVD, median 15.7 years). Weight loss, classified as change in BMI <-0.10 kg/m(2)/year, associated with increased all-cause mortality (adjusted HR: 1.30; 95% confidence interval [CI]: 1.12 to 1.50). Weight gain, classified as change in BMI >/=0.10 kg/m(2)/year, was not associated with increased mortality (adjusted HR: 0.97; 95% CI: 0.87 to 1.09). Weight loss only associated with increased risk in those who were normal weight at baseline (adjusted HR: 1.38; 95% CI: 1.11 to 1.72). There was a lower risk for all-cause mortality in participants who maintained low PA (adjusted HR: 0.81; 95% CI: 0.67 to 0.97) or high PA (adjusted HR: 0.64; 95% CI: 0.50 to 0.83), compared with participants who were inactive over time. CVD mortality associations were similar as for all-cause mortality. CONCLUSIONS: The study observed no mortality risk reductions associated with weight loss in individuals with CHD, and reduced mortality risk associated with weight gain in individuals who were normal weight at baseline. Sustained PA, however, was associated with substantial risk reduction.  
  Address Department of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway; Institute of Public Health, College of Medicine and Health Sciences, United Arab Emirates University, Al-Ain, United Arab Emirates  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0735-1097 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29519349 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 2137  
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