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Author (up) Muller, D.C.; Hodge, A.M.; Fanidi, A.; Albanes, D.; Mai, X.M.; Shu, X.O.; Weinstein, S.J.; Larose, T.L.; Zhang, X.; Han, J.; Stampfer, M.J.; Smith-Warner, S.A.; Ma, J.; Gaziano, J.M.; Sesso, H.D.; Stevens, V.L.; McCullough, M.L.; Layne, T.M.; Prentice, R.; Pettinger, M.; Thomson, C.A.; Zheng, W.; Gao, Y.T.; Rothman, N.; Xiang, Y.B.; Cai, H.; Wang, R.; Yuan, J.M.; Koh, W.P.; Butler, L.M.; Cai, Q.; Blot, W.J.; Wu, J.; Ueland, P.M.; Midttun, O.; Langhammer, A.; Hveem, K.; Johansson, M.; Hultdin, J.; Grankvist, K.; Arslan, A.A.; Le Marchand, L.; Severi, G.; Johansson, M.; Brennan, P. url  doi
  Title No association between circulating concentrations of vitamin D and risk of lung cancer: an analysis in 20 prospective studies in the Lung Cancer Cohort Consortium (LC3) Type Journal Article
  Year 2018 Publication Annals of Oncology : Official Journal of the European Society for Medical Oncology Abbreviated Journal Ann Oncol  
  Volume 29 Issue 6 Pages 1468-1475  
  Keywords  
  Abstract Background: There is observational evidence suggesting that high vitamin D concentrations may protect against lung cancer. To investigate this hypothesis in detail, we measured circulating vitamin D concentrations in prediagnostic blood from 20 cohorts participating in the Lung Cancer Cohort Consortium (LC3). Patients and methods: The study included 5313 lung cancer cases and 5313 controls. Blood samples for the cases were collected, on average, 5 years before lung cancer diagnosis. Controls were individually matched to the cases by cohort, sex, age, race/ethnicity, date of blood collection, and smoking status in five categories. Liquid chromatography coupled with tandem mass spectrometry was used to separately analyze 25-hydroxyvitamin D2 [25(OH)D2] and 25-hydroxyvitamin D3 [25(OH)D3] and their concentrations were combined to give an overall measure of 25(OH)D. We used conditional logistic regression to calculate odds ratios (ORs) and 95% confidence intervals (CIs) for 25(OH)D as both continuous and categorical variables. Results: Overall, no apparent association between 25(OH)D and risk of lung cancer was observed (multivariable adjusted OR for a doubling in concentration: 0.98, 95% CI: 0.91, 1.06). Similarly, we found no clear evidence of interaction by cohort, sex, age, smoking status, or histology. Conclusion: This study did not support an association between vitamin D concentrations and lung cancer risk.  
  Address Genetic Epidemiology Group, International Agency for Research on Cancer, Lyon, France  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0923-7534 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29617726; PMCID:PMC6005063 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 2139  
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