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Author (up) Naicker, K.; Manuel, D.; Overland, S.; Skogen, J.C.; Johnson, J.A.; Sivertsen, B.; Colman, I. url  doi
  Title Population attributable fractions for Type 2 diabetes: an examination of multiple risk factors including symptoms of depression and anxiety Type Journal Article
  Year 2018 Publication Diabetology & Metabolic Syndrome Abbreviated Journal Diabetol Metab Syndr  
  Volume 10 Issue Pages 84  
  Keywords Anxiety; Attributable fractions; Depression; Metabolic risk; Type 2 diabetes  
  Abstract Background: Population attributable fractions (PAFs) are frequently used to quantify the proportion of Type 2 diabetes cases due to single risk factors, an approach which may result in an overestimation of their individual contributions. This study aimed to examine Type 2 diabetes incidence associated with multiple risk factor combinations, including the metabolic syndrome, behavioural factors, and specifically, depression and anxiety. Methods: Using data from the population-based HUNT cohort, we examined incident diabetes in 36,161 Norwegian adults from 1995 to 2008. PAFs were calculated using Miettinen's case-based formula, using relative risks estimated from multivariate regression models. Results: Overall, the studied risk factors accounted for 50.5% of new diabetes cases (78.2% in men and 47.0% in women). Individuals exposed to both behavioural and metabolic factors were at highest risk of diabetes onset (PAF = 22.9%). Baseline anxiety and depression contributed a further 13.6% of new cases to this combination. Men appeared to be particularly vulnerable to the interaction between metabolic, behavioural and psychological risk factors. Conclusion: This study highlights the importance of risk factor clustering in diabetes onset, and is the first that we know of to quantify the excess fraction of incident diabetes associated with psychological risk factor interactions.  
  Address 1School of Epidemiology and Public Health, University of Ottawa, 600 Peter Morand Cres., Room 308C, Ottawa, ON K1G 5Z3 Canada.0000 0001 2182 2255grid.28046.38  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1758-5996 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30479670; PMCID:PMC6251110 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 2141  
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