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Author (up) Nielsen, J.B.; Thorolfsdottir, R.B.; Fritsche, L.G.; Zhou, W.; Skov, M.W.; Graham, S.E.; Herron, T.J.; McCarthy, S.; Schmidt, E.M.; Sveinbjornsson, G.; Surakka, I.; Mathis, M.R.; Yamazaki, M.; Crawford, R.D.; Gabrielsen, M.E.; Skogholt, A.H.; Holmen, O.L.; Lin, M.; Wolford, B.N.; Dey, R.; Dalen, H.; Sulem, P.; Chung, J.H.; Backman, J.D.; Arnar, D.O.; Thorsteinsdottir, U.; Baras, A.; O'Dushlaine, C.; Holst, A.G.; Wen, X.; Hornsby, W.; Dewey, F.E.; Boehnke, M.; Kheterpal, S.; Mukherjee, B.; Lee, S.; Kang, H.M.; Holm, H.; Kitzman, J.; Shavit, J.A.; Jalife, J.; Brummett, C.M.; Teslovich, T.M.; Carey, D.J.; Gudbjartsson, D.F.; Stefansson, K.; Abecasis, G.R.; Hveem, K.; Willer, C.J. url  doi
  Title Biobank-driven genomic discovery yields new insight into atrial fibrillation biology Type Journal Article
  Year 2018 Publication Nature Genetics Abbreviated Journal Nat Genet  
  Volume 50 Issue 9 Pages 1234-1239  
  Keywords  
  Abstract To identify genetic variation underlying atrial fibrillation, the most common cardiac arrhythmia, we performed a genome-wide association study of >1,000,000 people, including 60,620 atrial fibrillation cases and 970,216 controls. We identified 142 independent risk variants at 111 loci and prioritized 151 functional candidate genes likely to be involved in atrial fibrillation. Many of the identified risk variants fall near genes where more deleterious mutations have been reported to cause serious heart defects in humans (GATA4, MYH6, NKX2-5, PITX2, TBX5)(1), or near genes important for striated muscle function and integrity (for example, CFL2, MYH7, PKP2, RBM20, SGCG, SSPN). Pathway and functional enrichment analyses also suggested that many of the putative atrial fibrillation genes act via cardiac structural remodeling, potentially in the form of an 'atrial cardiomyopathy'(2), either during fetal heart development or as a response to stress in the adult heart.  
  Address Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA. cristen@umich.edu  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1061-4036 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30061737 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 2144  
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