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Author (up) Rangul, V.; Sund, E.R.; Mork, P.J.; Roe, O.D.; Bauman, A. url  doi
  Title The associations of sitting time and physical activity on total and site-specific cancer incidence: Results from the HUNT study, Norway Type Journal Article
  Year 2018 Publication PloS one Abbreviated Journal PLoS One  
  Volume 13 Issue 10 Pages e0206015  
  Keywords  
  Abstract BACKGROUND: Sedentary behavior is thought to pose different risks to those attributable to physical inactivity. However, few studies have examined the association between physical activity and sitting time with cancer incidence within the same population. METHODS: We followed 38,154 healthy Norwegian adults in the Nord-Trondelag Health Study (HUNT) for cancer incidence from 1995-97 to 2014. Cox proportional hazards regression was used to estimate risk of site-specific and total cancer incidence by baseline sitting time and physical activity. RESULTS: During the 16-years follow-up, 4,196 (11%) persons were diagnosed with cancer. We found no evidence that people who had prolonged sitting per day or had low levels of physical activity had an increased risk of total cancer incidence, compared to those who had low sitting time and were physically active. In the multivariate model, sitting >/=8 h/day was associated with 22% (95% CI, 1.05-1.42) higher risk of prostate cancer compared to sitting <8 h/day. Further, men with low physical activity (</=8.3 MET-h/week) had 31% (95% CI, 1.00-1.70) increased risk of colorectal cancer (CRC) and 45% (95% CI, 1.01-2.09) increased risk of lung cancer compared to participants with a high physical activity (>16.6 MET-h/week). The joint effects of physical activity and sitting time the indicated that prolonged sitting time increased the risk of CRC independent of physical activity in men. CONCLUSIONS: Our findings suggest that prolonged sitting and low physical activity are positively associated with colorectal-, prostate- and lung cancer among men. Sitting time and physical activity were not associated with cancer incidence among women. The findings emphasizing the importance of reducing sitting time and increasing physical activity.  
  Address Prevention Research Collaboration, School of Public Health, University of Sydney, New South Wales, Sydney, Australia  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1932-6203 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30352079; PMCID:PMC6198967 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 2146  
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