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Author (up) Snekvik, I.; Nilsen, T.I.L.; Romundstad, P.R.; Saunes, M. url  doi
  Title Psoriasis and cardiovascular disease risk factors: the HUNT Study, Norway Type Journal Article
  Year 2018 Publication Journal of the European Academy of Dermatology and Venereology : JEADV Abbreviated Journal J Eur Acad Dermatol Venereol  
  Volume 32 Issue 5 Pages 776-782  
  Keywords Adult; Aged; Angina Pectoris/epidemiology; *Body Mass Index; C-Reactive Protein/*metabolism; Cross-Sectional Studies; Diabetes Mellitus/epidemiology; Female; Humans; Male; Metabolic Syndrome/epidemiology; Middle Aged; Myocardial Infarction/epidemiology; Norway/epidemiology; Overweight/epidemiology; Psoriasis/*epidemiology; Risk Factors; Severity of Illness Index; *Waist Circumference; Young Adult  
  Abstract BACKGROUND: Studies have examined the associations between psoriasis and cardiovascular diseases and their risk factors, but the results are conflicting, especially in the general population. OBJECTIVES: To investigate the association of psoriasis, and in particular psoriasis severity, with objectively measured cardiovascular disease risk factors and cardiovascular morbidity in a large population-based cross-sectional study. METHODS: We linked data on 50 245 persons in the HUNT3 Study, Norway, with information from the National Prescription Database to obtain information on use of psoriasis medication. A total of 2894 persons reported to have psoriasis; 2643 were classified as mild; and 251 as moderate/severe psoriasis. We used linear and logistic regression to estimate adjusted associations with 95% confidence intervals (CIs) between psoriasis and cardiovascular disease risk factors and morbidity. RESULTS: We observed a positive association between psoriasis and objective measures of body mass index (BMI), waist circumference and high-sensitivity C-reactive protein, but no clear association with blood pressure and blood lipids. People with moderate/severe psoriasis had an odds ratio for being overweight of 1.94 (95% CI 1.42, 2.67), whereas the odds ratio for metabolic syndrome was 1.91 (95% CI 1.47, 2.49). Psoriasis was also positively associated with self-reported diabetes, myocardial infarction and angina pectoris. CONCLUSIONS: In this population-based study, we found that psoriasis was positively associated with measures of adiposity, as well as with a clustering of cardiovascular disease risk factors. Overall, these associations were strongest for people with moderate/severe psoriasis.  
  Address Department of Cancer Research and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0926-9959 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29397035 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 2155  
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