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Author (up) Sorli, K.; Thorvaldsen, S.M.; Hatlen, P. url  doi
  Title Use of Inhaled Corticosteroids and the Risk of Lung Cancer, the HUNT Study Type Journal Article
  Year 2018 Publication Lung Abbreviated Journal Lung  
  Volume 196 Issue 2 Pages 179-184  
  Keywords *Copd; *Ics; *Lung cancer  
  Abstract BACKGROUND: Inflammation plays a central role in chronic obstructive pulmonary disease and lung cancer carcinogenesis. Inhaled corticosteroids (ICS) reduce inflammation. This study has investigated whether ICS use is associated with a lower risk of lung cancer. MATERIALS AND METHODS: Data from the Nord-Trondelag Health Study (HUNT2 Survey, 1995-1997) were merged with The Cancer Registry of Norway and Norwegian Cause of Death Registry. From a total of 65,215 participants, those with chronic airway inflammation, defined by FEV1% < 70 and/or chronic cough and expectorate phlegm, were included (N = 4136). Of these, 3041 individuals reported regarding ICS use and were observed for a period of 12 years. Cox regression models were used to calculate the risk of lung cancer with a 95% confidence interval (CI) with sex, age, smoking pack years and FEV1% < 70 as known confounders. RESULTS: Among ICS users (N = 1095). we found a higher, but not significant, incidence of lung cancer N = 39 (3.6%), compared to non-users (N = 1946) with N = 65 (3.3%) cases. Age and smoking were associated with a higher risk, while sex and lung function were not. After adjusting for confounders, ICS use did not change the risk of lung cancer, hazard ratio (HR) 0.968, (95% CI, 0.608-1.540), and p value 0.890. CONCLUSION: ICS use is not associated with a reduced risk of lung cancer in our study population.  
  Address Department of Circulation and Medical Imaging (ISB), Faculty of Medicine and Health Sciences, NTNU, 7489, Trondheim, Norway.  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0341-2040 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29427221 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 2159  
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