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Author (up) Stoylen, A.; Molmen, H.E.; Dalen, H. url  doi
  Title Relation between Mitral Annular Plane Systolic Excursion and Global longitudinal strain in normal subjects: The HUNT study Type Journal Article
  Year 2018 Publication Echocardiography (Mount Kisco, N.Y.) Abbreviated Journal Echocardiography  
  Volume 35 Issue 5 Pages 603-610  
  Keywords Echocardiography/*methods; Female; Heart Ventricles/*diagnostic imaging/physiopathology; Humans; Male; Middle Aged; Mitral Valve/*diagnostic imaging; Prospective Studies; Reference Values; Stroke Volume; Systole; Ventricular Dysfunction, Left/diagnosis/*physiopathology; Ventricular Function, Left/*physiology; *global longitudinal strain; *left ventricular shortening; *mitral annular plane systolic excursion; *normalization  
  Abstract BACKGROUND: Left ventricular (LV) systolic long-axis shortening can be measured as Mitral Annular Plane Systolic Excursion (MAPSE). Global longitudinal strain (GLS) is relative LV shortening, equivalent to normalizing MAPSE for LV length (MAPSEn). The objective of this study was to test whether normalizing LV shortening reduced biological variability of MAPSE due to normalizing for heart size and, possibly BSA. Secondly to provide normal reference values for MAPSE. METHODS AND RESULTS: A total of 1266 subjects from the Nord-Trondelag Health Study (HUNT), without evidence of heart disease were examined. MAPSE and wall lengths were measured in all three standard apical views, while GLS has been published previously. Mean MAPSE was 1.58 (0.25) cm, MAPSEn 16.3 (2.4)%, and GLS 16.7 (2.4)%. All measures declined with age, correlations between -0.50 and -0.41. MAPSE was gender independent, and less BSA dependent than MAPSEn and GLS, while relative standard deviations (SDs) were similar for all three measures. CONCLUSIONS: MAPSE, MAPSEn, and GLS have similar biological variability, which is mainly due to age variation, indicating they are equivalent in normal, and normalizing for BSA will not reduce the variability. Normalizing MAPSE for LV length (MAPSEn and GLS) normalizes for one dimension only, inducing a systematic error, which increases BSA and gender dependence. Normal age-related, gender-independent values for MAPSE are provided.  
  Address Department of Medicine, Levanger Hospital, Nord-Trondelag Hospital Trust, Levanger, Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0742-2822 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29399886 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 2176  
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