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Author (up) Sun, Y.-Q.; Brumpton, B.M.; Bonilla, C.; Lewis, S.J.; Burgess, S.; Skorpen, F.; Chen, Y.; Nilsen, T.I.L.; Romundstad, P.R.; Mai, X.-M. url  doi
  Title Serum 25-hydroxyvitamin D levels and risk of lung cancer and histologic types: a Mendelian randomisation analysis of the HUNT study Type Journal Article
  Year 2018 Publication The European Respiratory Journal Abbreviated Journal Eur Respir J  
  Volume 51 Issue 6 Pages  
  Keywords  
  Abstract We aimed to investigate potential causal associations between serum 25-hydroxyvitamin D (25(OH)D) levels and incidence of lung cancer overall and histologic types.We performed a Mendelian randomisation analysis using a prospective cohort study in Norway, including 54 580 individuals and 676 incident lung cancer cases. A 25(OH)D allele score was generated based on the vitamin D-increasing alleles rs2282679, rs12785878 and rs10741657. Hazard ratios with 95% confidence intervals for incidence of lung cancer and histologic types were estimated in relation to the allele score. The inverse-variance weighted method using summarised data of individual single nucleotide polymorphisms was applied to calculate the Mendelian randomisation estimates.The allele score accounted for 3.4% of the variation in serum 25(OH)D levels. There was no association between the allele score and lung cancer incidence overall, with HR 0.99 (95% CI 0.93-1.06) per allele score. A 25 nmol.L(-1) increase in genetically determined 25(OH)D level was not associated with the incidence of lung cancer overall (Mendelian randomisation estimate HR 0.96, 95% CI 0.54-1.69) or any histologic type.Mendelian randomisation analysis did not suggest a causal association between 25(OH)D levels and risk of lung cancer overall or histologic types in this population-based cohort study.  
  Address Dept of Public Health and Nursing, Norwegian University of Science and Technology (NTNU), Trondheim, Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0903-1936 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29748306 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 2177  
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