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Author (up) Tanskanen, T.; van den Berg, L.; Valimaki, N.; Aavikko, M.; Ness-Jensen, E.; Hveem, K.; Wettergren, Y.; Bexe Lindskog, E.; Tonisson, N.; Metspalu, A.; Silander, K.; Orlando, G.; Law, P.J.; Tuupanen, S.; Gylfe, A.E.; Hanninen, U.A.; Cajuso, T.; Kondelin, J.; Sarin, A.-P.; Pukkala, E.; Jousilahti, P.; Salomaa, V.; Ripatti, S.; Palotie, A.; Jarvinen, H.; Renkonen-Sinisalo, L.; Lepisto, A.; Bohm, J.; Mecklin, J.-P.; Al-Tassan, N.A.; Palles, C.; Martin, L.; Barclay, E.; Tenesa, A.; Farrington, S.M.; Timofeeva, M.N.; Meyer, B.F.; Wakil, S.M.; Campbell, H.; Smith, C.G.; Idziaszczyk, S.; Maughan, T.S.; Kaplan, R.; Kerr, R.; Kerr, D.; Buchanan, D.D.; Win, A.K.; Hopper, J.; Jenkins, M.A.; Newcomb, P.A.; Gallinger, S.; Conti, D.; Schumacher, F.R.; Casey, G.; Cheadle, J.P.; Dunlop, M.G.; Tomlinson, I.P.; Houlston, R.S.; Palin, K.; Aaltonen, L.A. url  doi
  Title Genome-wide association study and meta-analysis in Northern European populations replicate multiple colorectal cancer risk loci Type Journal Article
  Year 2018 Publication International Journal of Cancer Abbreviated Journal Int J Cancer  
  Volume 142 Issue 3 Pages 540-546  
  Keywords Case-Control Studies; Cohort Studies; Colorectal Neoplasms/*epidemiology/*genetics; Estonia/epidemiology; Finland/epidemiology; Genetic Predisposition to Disease; Genome-Wide Association Study; Humans; Polymorphism, Single Nucleotide; Registries; *colorectal cancer; *genetic predisposition to disease; *genome-wide association study; *single-nucleotide polymorphism  
  Abstract Genome-wide association studies have been successful in elucidating the genetic basis of colorectal cancer (CRC), but there remains unexplained variability in genetic risk. To identify new risk variants and to confirm reported associations, we conducted a genome-wide association study in 1,701 CRC cases and 14,082 cancer-free controls from the Finnish population. A total of 9,068,015 genetic variants were imputed and tested, and 30 promising variants were studied in additional 11,647 cases and 12,356 controls of European ancestry. The previously reported association between the single-nucleotide polymorphism (SNP) rs992157 (2q35) and CRC was independently replicated (p = 2.08 x 10(-4) ; OR, 1.14; 95% CI, 1.06-1.23), and it was genome-wide significant in combined analysis (p = 1.50 x 10(-9) ; OR, 1.12; 95% CI, 1.08-1.16). Variants at 2q35, 6p21.2, 8q23.3, 8q24.21, 10q22.3, 10q24.2, 11q13.4, 11q23.1, 14q22.2, 15q13.3, 18q21.1, 20p12.3 and 20q13.33 were associated with CRC in the Finnish population (false discovery rate < 0.1), but new risk loci were not found. These results replicate the effects of multiple loci on the risk of CRC and identify shared risk alleles between the Finnish population isolate and outbred populations.  
  Address Genome-Scale Biology Research Program, Research Programs Unit, University of Helsinki, Helsinki, Finland  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0020-7136 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:28960316 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 2180  
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