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Author (up) van Duijnhoven, F.J.B.; Jenab, M.; Hveem, K.; Siersema, P.D.; Fedirko, V.; Duell, E.J.; Kampman, E.; Halfweeg, A.; van Kranen, H.J.; van den Ouweland, J.M.W.; Weiderpass, E.; Murphy, N.; Langhammer, A.; Ness-Jensen, E.; Olsen, A.; Tjonneland, A.; Overvad, K.; Cadeau, C.; Kvaskoff, M.; Boutron-Ruault, M.-C.; Katzke, V.A.; Kuhn, T.; Boeing, H.; Trichopoulou, A.; Kotanidou, A.; Kritikou, M.; Palli, D.; Agnoli, C.; Tumino, R.; Panico, S.; Matullo, G.; Peeters, P.; Brustad, M.; Olsen, K.S.; Lasheras, C.; Obon-Santacana, M.; Sanchez, M.-J.; Dorronsoro, M.; Chirlaque, M.-D.; Barricarte, A.; Manjer, J.; Almquist, M.; Renstrom, F.; Ye, W.; Wareham, N.; Khaw, K.-T.; Bradbury, K.E.; Freisling, H.; Aune, D.; Norat, T.; Riboli, E.; Bueno-de-Mesquita, H.B.A. url  doi
  Title Circulating concentrations of vitamin D in relation to pancreatic cancer risk in European populations Type Journal Article
  Year 2018 Publication International Journal of Cancer Abbreviated Journal Int J Cancer  
  Volume 142 Issue 6 Pages 1189-1201  
  Keywords 25-Hydroxyvitamin D 2/*blood; Aged; Calcifediol/*blood; Case-Control Studies; Europe; Female; Follow-Up Studies; Humans; Incidence; Male; Middle Aged; Pancreatic Neoplasms/blood/*epidemiology; Prospective Studies; Risk Assessment; Seasons; *cancer epidemiology; *nested case-control study; *pancreatic cancer; *vitamin D  
  Abstract Evidence from in vivo, in vitro and ecological studies are suggestive of a protective effect of vitamin D against pancreatic cancer (PC). However, this has not been confirmed by analytical epidemiological studies. We aimed to examine the association between pre-diagnostic circulating vitamin D concentrations and PC incidence in European populations. We conducted a pooled nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) and the Nord-Trondelag Health Study's second survey (HUNT2) cohorts. In total, 738 primary incident PC cases (EPIC n = 626; HUNT2 n = 112; median follow-up = 6.9 years) were matched to 738 controls. Vitamin D [25(OH)D2 and 25(OH)D3 combined] concentrations were determined using isotope-dilution liquid chromatography-tandem mass spectrometry. Conditional logistic regression models with adjustments for body mass index and smoking habits were used to estimate incidence rate ratios (IRRs) and 95% confidence intervals (95%CI). Compared with a reference category of >50 to 75 nmol/L vitamin D, the IRRs (95% CIs) were 0.71 (0.42-1.20); 0.94 (0.72-1.22); 1.12 (0.82-1.53) and 1.26 (0.79-2.01) for clinically pre-defined categories of </=25; >25 to 50; >75 to 100; and >100 nmol/L vitamin D, respectively (p for trend = 0.09). Corresponding analyses by quintiles of season-standardized vitamin D concentrations also did not reveal associations with PC risk (p for trend = 0.23). Although these findings among participants from the largest combination of European cohort studies to date show increasing effect estimates of PC risk with increasing pre-diagnostic concentrations of vitamin D, they are not statistically significant.  
  Address Department of Social and Preventive Medicine, Faculty of Medicine, University of Malaya, Kuala Lumpur, Malaysia  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 0020-7136 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:29114875; PMCID:PMC5813219 Approved no  
  Call Number HUNT @ maria.stuifbergen @ Serial 2186  
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