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Author (up) Zotcheva, E.; Bergh, S.; Selbaek, G.; Krokstad, S.; Haberg, A.K.; Strand, B.H.; Ernstsen, L. url  doi
  Title Midlife Physical Activity, Psychological Distress, and Dementia Risk: The HUNT Study Type Journal Article
  Year 2018 Publication Journal of Alzheimer's Disease : JAD Abbreviated Journal J Alzheimers Dis  
  Volume 66 Issue 2 Pages 825-833  
  Keywords Anxiety; cognition; dementia; depression; exercise; psychological stress  
  Abstract BACKGROUND: Physical activity (PA) is associated with a decreased dementia risk, whereas psychological distress (distress) is linked to an increased dementia risk. OBJECTIVE: We investigated independent and joint associations of midlife moderate-to-vigorous PA (MVPA) and distress with incident dementia. METHODS: Our study comprised 28,916 participants aged 30-60 years from the Nord-Trondelag Health Study (HUNT1, 1984-1986). Data on MVPA and distress from HUNT1 was linked to the Health and Memory Study in Nord-Trondelag for dementia case identification. Participants were followed from 1995 until 2011. We used adjusted Cox regression models to estimate hazard ratios (HRs) and 95% confidence intervals (95% CI). RESULTS: In fully adjusted analyses, MVPA was associated with a reduced dementia risk (HR 0.81, 95% CI 0.62-1.06), compared to no MVPA. Distress was associated with an increased dementia risk (HR 1.30, 95% CI 0.99-1.70). Compared to distressed participants not taking part in MVPA, non-distressed no-MVPA participants had a reduced dementia risk (HR 0.72, 95% CI 0.54-0.96). The same applied to distressed MVPA participants (HR 0.50, 95% CI 0.22-1.14), and non-distressed MVPA participants (HR 0.63, 95% CI 0.44-0.90). Our results indicated an additive interaction between MVPA and distress on dementia risk. CONCLUSION: Our results suggest that midlife MVPA reduces risk of incident dementia among both distressed and non-distressed individuals.  
  Address Department of Public Health and Nursing, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway  
  Corporate Author Thesis  
  Publisher Place of Publication Editor  
  Language English Summary Language Original Title  
  Series Editor Series Title Abbreviated Series Title  
  Series Volume Series Issue Edition  
  ISSN 1387-2877 ISBN Medium  
  Area Expedition Conference  
  Notes PMID:30320592 Approved no  
  Call Number HUNT @ maria.stuifbergen @; NTNU @ ingunn.grytting @ Serial 2193  
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