TY  - JOUR
AU  - Michelsen, T. M.
AU  - Dorum, A.
AU  - Cvancarova, M.
AU  - Liavaag, A. H.
AU  - Dahl, A. A.
PY  - 2013
DA  - 2013//
TI  - Association between hysterectomy with ovarian preservation and cardiovascular disease in a Norwegian population-based sample
T2  - Gynecol Obstet Invest
JO  - Gynecologic and Obstetric Investigation
SP  - 61
EP  - 67
VL  - 75
IS  - 1
KW  - Aged
KW  - Antihypertensive Agents/therapeutic use
KW  - Body Mass Index
KW  - Cardiovascular Diseases/*epidemiology
KW  - Case-Control Studies
KW  - Cross-Sectional Studies
KW  - Diabetes Mellitus/epidemiology
KW  - Female
KW  - Health Surveys
KW  - Hormone Replacement Therapy/utilization
KW  - Humans
KW  - Hysterectomy/*statistics & numerical data
KW  - Middle Aged
KW  - Norway/epidemiology
KW  - Ovariectomy
KW  - Prevalence
KW  - Questionnaires
KW  - Risk Factors
AB  - BACKGROUND/AIMS: Some previous studies have reported that hysterectomy predicts increased prevalence of cardiovascular diseases, but the findings are disputed. We aimed to examine associations between hysterectomy and cardiovascular disease in a Norwegian cross-sectional health study. METHODS: The data were obtained from the population-based cross-sectional Nord-Trondelag Health Study (The HUNT-2 Study). Of 46,709 invited females, 35,280 (76%) participated; 939 (3%) reported hysterectomy without oophorectomy (exposed women). Each exposed woman was age-matched with four randomly chosen women (n = 3,756) without hysterectomy or oophorectomy. Oophorectomy and hysterectomy status was self-reported by the women. Hazard ratio for cardiovascular diseases was calculated by Cox regression analyses with hysterectomy as a time-dependent covariate. RESULTS: Median time since hysterectomy was 14 years (range 0-56 years). We calculated a significantly larger cumulative probability of cardiovascular diseases after hysterectomy with a hazard ratio of 1.92, 95% CI (1.51-2.38) after adjustments for cardiovascular risk factors (diabetes, age, use of hormonal replacement therapy and positive family history of myocardial infarction). CONCLUSION: Women had a significantly increased risk of cardiovascular diseases after hysterectomy compared to age-matched controls. Studies with longitudinal design and confirmed medical outcome data are needed.
SN  - 0378-7346
UR  - http://www.ncbi.nlm.nih.gov/pubmed/23220872
UR  - https://doi.org/10.1159/000345072
DO  - 10.1159/000345072
LA  - English
N1  - PMID:23220872
ID  - Michelsen_etal2013
ER  -