@Article{Berndt_etal2013,
author="Berndt, S. I.
and Gustafsson, S.
and Magi, R.
and Ganna, A.
and Wheeler, E.
and Feitosa, M. F.
and Justice, A. E.
and Monda, K. L.
and Croteau-Chonka, D. C.
and Day, F. R.
and Esko, T.
and Fall, T.
and Ferreira, T.
and Gentilini, D.
and Jackson, A. U.
and Luan, J. an
and Randall, J. C.
and Vedantam, S.
and Willer, C. J.
and Winkler, T. W.
and Wood, A. R.
and Workalemahu, T.
and Hu, Y-J
and Lee, S. H.
and Liang, L.
and Lin, D-Y
and Min, J. L.
and Neale, B. M.
and Thorleifsson, G.
and Yang, J.
and Albrecht, E.
and Amin, N.
and Bragg-Gresham, J. L.
and Cadby, G.
and den Heijer, M.
and Eklund, N.
and Fischer, K.
and Goel, A.
and Hottenga, J-J
and Huffman, J. E.
and Jarick, I.
and Johansson, A.
and Johnson, T.
and Kanoni, S.
and Kleber, M. E.
and Konig, I. R.
and Kristiansson, K.
and Kutalik, Z.
and Lamina, C.
and Lecoeur, C.
and Li, G.
and Mangino, M.
and McArdle, W. L.
and Medina-Gomez, C.
and Muller-Nurasyid, M.
and Ngwa, J. S.
and Nolte, I. M.
and Paternoster, L.
and Pechlivanis, S.
and Perola, M.
and Peters, M. J.
and Preuss, M.
and Rose, L. M.
and Shi, J.
and Shungin, D.
and Smith, A. V.
and Strawbridge, R. J.
and Surakka, I.
and Teumer, A.
and Trip, M. D.
and Tyrer, J.
and Van Vliet-Ostaptchouk, J. V.
and Vandenput, L.
and Waite, L. L.
and Zhao, J. H.
and Absher, D.
and Asselbergs, F. W.
and Atalay, M.
and Attwood, A. P.
and Balmforth, A. J.
and Basart, H.
and Beilby, J.
and Bonnycastle, L. L.
and Brambilla, P.
and Bruinenberg, M.
and Campbell, H.
and Chasman, D. I.
and Chines, P. S.
and Collins, F. S.
and Connell, J. M.
and Cookson, W. O.
and de Faire, U.
and de Vegt, F.
and Dei, M.
and Dimitriou, M.
and Edkins, S.
and Estrada, K.
and Evans, D. M.
and Farrall, M.
and Ferrario, M. M.
and Ferrieres, J.
and Franke, L.
and Frau, F.
and Gejman, P. V.
and Grallert, H.
and Gronberg, H.
and Gudnason, V.
and Hall, A. S.
and Hall, P.
and Hartikainen, A-L
and Hayward, C.
and Heard-Costa, N. L.
and Heath, A. C.
and Hebebrand, J.
and Homuth, G.
and Hu, F. B.
and Hunt, S. E.
and Hypponen, E.
and Iribarren, C.
and Jacobs, K. B.
and Jansson, J-O
and Jula, A.
and Kahonen, M.
and Kathiresan, S.
and Kee, F.
and Khaw, K-T
and Kivimaki, M.
and Koenig, W.
and Kraja, A. T.
and Kumari, M.
and Kuulasmaa, K.
and Kuusisto, J.
and Laitinen, J. H.
and Lakka, T. A.
and Langenberg, C.
and Launer, L. J.
and Lind, L.
and Lindstrom, J.
and Liu, J.
and Liuzzi, A.
and Lokki, M-L
and Lorentzon, M.
and Madden, P. A.
and Magnusson, P. K.
and Manunta, P.
and Marek, D.
and Marz, W.
and Mateo Leach, I.
and McKnight, B.
and Medland, S. E.
and Mihailov, E.
and Milani, L.
and Montgomery, G. W.
and Mooser, V.
and Muhleisen, T. W.
and Munroe, P. B.
and Musk, A. W.
and Narisu, N.
and Navis, G.
and Nicholson, G.
and Nohr, E. A.
and Ong, K. K.
and Oostra, B. A.
and Palmer, C. N. A.
and Palotie, A.
and Peden, J. F.
and Pedersen, N.
and Peters, A.
and Polasek, O.
and Pouta, A.
and Pramstaller, P. P.
and Prokopenko, I.
and Putter, C.
and Radhakrishnan, A.
and Raitakari, O.
and Rendon, A.
and Rivadeneira, F.
and Rudan, I.
and Saaristo, T. E.
and Sambrook, J. G.
and Sanders, A. R.
and Sanna, S.
and Saramies, J.
and Schipf, S.
and Schreiber, S.
and Schunkert, H.
and Shin, S-Y
and Signorini, S.
and Sinisalo, J.
and Skrobek, B.
and Soranzo, N.
and Stancakova, A.
and Stark, K.
and Stephens, J. C.
and Stirrups, K.
and Stolk, R. P.
and Stumvoll, M.
and Swift, A. J.
and Theodoraki, E. V.
and Thorand, B.
and Tregouet, D-A
and Tremoli, E.
and Van der Klauw, M. M.
and van Meurs, J. B. J.
and Vermeulen, S. H.
and Viikari, J.
and Virtamo, J.
and Vitart, V.
and Waeber, G.
and Wang, Z.
and Widen, E.
and Wild, S. H.
and Willemsen, G.
and Winkelmann, B. R.
and Witteman, J. C. M.
and Wolffenbuttel, B. H. R.
and Wong, A.
and Wright, A. F.
and Zillikens, M. C.
and Amouyel, P.
and Boehm, B. O.
and Boerwinkle, E.
and Boomsma, D. I.
and Caulfield, M. J.
and Chanock, S. J.
and Cupples, L. A.
and Cusi, D.
and Dedoussis, G. V.
and Erdmann, J.
and Eriksson, J. G.
and Franks, P. W.
and Froguel, P.
and Gieger, C.
and Gyllensten, U.
and Hamsten, A.
and Harris, T. B.
and Hengstenberg, C.
and Hicks, A. A.
and Hingorani, A.
and Hinney, A.
and Hofman, A.
and Hovingh, K. G.
and Hveem, K.
and Illig, T.
and Jarvelin, M-R
and Jockel, K-H
and Keinanen-Kiukaanniemi, S. M.
and Kiemeney, L. A.
and Kuh, D.
and Laakso, M.
and Lehtimaki, T.
and Levinson, D. F.
and Martin, N. G.
and Metspalu, A.
and Morris, A. D.
and Nieminen, M. S.
and Njolstad, I.
and Ohlsson, C.
and Oldehinkel, A. J.
and Ouwehand, W. H.
and Palmer, L. J.
and Penninx, B.
and Power, C.
and Province, M. A.
and Psaty, B. M.
and Qi, L.
and Rauramaa, R.
and Ridker, P. M.
and Ripatti, S.
and Salomaa, V.
and Samani, N. J.
and Snieder, H.
and Sorensen, T. I. A.
and Spector, T. D.
and Stefansson, K.
and Tonjes, A.
and Tuomilehto, J.
and Uitterlinden, A. G.
and Uusitupa, M.
and van der Harst, P.
and Vollenweider, P.
and Wallaschofski, H.
and Wareham, N. J.
and Watkins, H.
and Wichmann, H-E
and Wilson, J. F.
and Abecasis, G. R.
and Assimes, T. L.
and Barroso, I.
and Boehnke, M.
and Borecki, I. B.
and Deloukas, P.
and Fox, C. S.
and Frayling, T.
and Groop, L. C.
and Haritunian, T.
and Heid, I. M.
and Hunter, D.
and Kaplan, R. C.
and Karpe, F.
and Moffatt, M. F.
and Mohlke, K. L.
and O{\textquoteright}Connell, J. R.
and Pawitan, Y.
and Schadt, E. E.
and Schlessinger, D.
and Steinthorsdottir, V.
and Strachan, D. P.
and Thorsteinsdottir, U.
and van Duijn, C. M.
and Visscher, P. M.
and Di Blasio, A. M.
and Hirschhorn, J. N.
and Lindgren, C. M.
and Morris, A. P.
and Meyre, D.
and Scherag, A.
and McCarthy, M. I.
and Speliotes, E. K.
and North, K. E.
and Loos, R. J. F.
and Ingelsson, E.",
title="Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture",
journal="Nature Genetics",
year="2013",
volume="45",
number="5",
pages="501--512",
optkeywords="*Anthropometry; Body Height/*genetics; Body Mass Index; Case-Control Studies; European Continental Ancestry Group/genetics; *Genetic Predisposition to Disease; *Genome-Wide Association Study; Genotype; Humans; Meta-Analysis as Topic; Obesity/*genetics; Phenotype; Polymorphism; Single Nucleotide/*genetics; *Quantitative Trait Loci; Waist-Hip Ratio",
abstract="Approaches exploiting trait distribution extremes may be used to identify loci associated with common traits, but it is unknown whether these loci are generalizable to the broader population. In a genome-wide search for loci associated with the upper versus the lower 5th percentiles of body mass index, height and waist-to-hip ratio, as well as clinical classes of obesity, including up to 263,407 individuals of European ancestry, we identified 4 new loci (IGFBP4, H6PD, RSRC1 and PPP2R2A) influencing height detected in the distribution tails and 7 new loci (HNF4G, RPTOR, GNAT2, MRPS33P4, ADCY9, HS6ST3 and ZZZ3) for clinical classes of obesity. Further, we find a large overlap in genetic structure and the distribution of variants between traits based on extremes and the general population and little etiological heterogeneity between obesity subgroups.",
optnote="PMID:23563607",
optnote="exported from refbase (http://vev.medisin.ntnu.no/refbase/show.php?record=1466), last updated on Thu, 13 Feb 2014 22:18:21 +0100",
issn="1061-4036",
doi="10.1038/ng.2606",
opturl="http://www.ncbi.nlm.nih.gov/pubmed/23563607",
opturl="https://doi.org/10.1038/ng.2606",
language="English"
}