PT Journal
AU Mai, X
   Chen, Y
   Camargo, CAJ
   Langhammer, A
TI Cross-sectional and prospective cohort study of serum 25-hydroxyvitamin D level and obesity in adults: the HUNT study
SO American Journal of Epidemiology
JI Am J Epidemiol
PY 2012
BP 1029
EP 1036
VL 175
IS 10
DI 10.1093/aje/kwr456
LA English
DE Adult; Biological Markers/blood; Body Mass Index; Cross-Sectional Studies; Female; Follow-Up Studies; Health Surveys; Humans; Hydroxycholecalciferols/blood/*deficiency; Incidence; Linear Models; Logistic Models; Male; Middle Aged; Multivariate Analysis; Norway/epidemiology; Obesity/blood/epidemiology/*etiology; Odds Ratio; Prevalence; Prospective Studies; Vitamin D Deficiency/blood/*complications; Waist Circumference
AB Experimental studies suggest that vitamin D modulates the activity of adipocytes. The authors examined baseline serum 25-hydroxyvitamin D (25(OH)D) level in relation to prevalent and cumulative incident obesity in Norway. A cohort of 25,616 adults aged 19-55 years participated in both the second and third surveys of the Nord-Trondelag Health Study (HUNT 2 (1995-1997) and HUNT 3 (2006-2008)). Serum 25(OH)D levels measured at baseline and anthropometric measurements taken at both baseline and follow-up were available for a random sample of 2,460 subjects. Overall, 40% of the 2,460 subjects had a serum 25(OH)D level less than 50.0 nmol/L, and 37% had a level of 50.0-74.9 nmol/L. The prevalence and cumulative incidence of obesity, defined as body mass index (weight (kg)/height (m)(2)) >/=30, were 12% and 15%, respectively. Lower serum 25(OH)D level was associated with a higher prevalence of obesity. In the 2,165 subjects with baseline BMI less than 30, a serum 25(OH)D level less than 50.0 nmol/L was associated with a significantly increased odds ratio for incident obesity during follow-up (adjusted odds ratio = 1.73, 95% confidence interval: 1.24, 2.41). When prevalent and incident obesity were classified according to waist circumference (>/=88 cm for women, >/=102 cm for men), similar results were obtained. In addition to prevalent obesity, a serum 25(OH)D level less than 50.0 nmol/L was significantly associated with new-onset obesity in adults.
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