PT Journal AU Chau, JY Grunseit, A Midthjell, K Holmen, J Holmen, TL Bauman, AE Van der Ploeg, HP TI Sedentary behaviour and risk of mortality from all-causes and cardiometabolic diseases in adults: evidence from the HUNT3 population cohort SO Br J Sports Med JI British journal of sports medicine PY 2015 BP 737 EP 742 VL 49 IS 11 DE HUNT3; Adult; Age Distribution; Aged; Cardiovascular Diseases/*mortality; Cause of Death; Female; Humans; Leisure Activities; Male; Metabolic Diseases/*mortality; Middle Aged; Norway/epidemiology; Occupational Health/statistics & numerical data; Prospective Studies; Risk Factors; *Sedentary Lifestyle; Sex Distribution; Young Adult AB BACKGROUND: Sedentary behaviour is a potential risk factor for chronic-ill health and mortality, that is, independent of health-enhancing physical activity. Few studies have investigated the risk of mortality associated with multiple contexts of sedentary behaviour. OBJECTIVE: To examine the prospective associations of total sitting time, TV-viewing time and occupational sitting with mortality from all causes and cardiometabolic diseases. METHODS: Data from 50,817 adults aged >/=20 years from the Nord-Trondelag Health Study 3 (HUNT3) in 2006-2008 were linked to the Norwegian Cause of Death Registry up to 31 December 2010. Cox proportional hazards models examined all-cause and cardiometabolic disease-related mortality associated with total sitting time, TV-viewing and occupational sitting, adjusting for multiple potential confounders including physical activity. RESULTS: After mean follow-up of 3.3 years (137,315.8 person-years), 1068 deaths were recorded of which 388 were related to cardiometabolic diseases. HRs for all-cause mortality associated with total sitting time were 1.12 (95% CI 0.89 to 1.42), 1.18 (95% CI 0.90 to 1.57) and 1.65 (95% CI 1.24 to 2.21) for total sitting time 4- PI Prevention Research Collaboration, Sydney School of Public Health, University of Sydney, Sydney, Aus ER