@Article{Iversen_etal2015,
author="Iversen, M. M.
and Tell, G. S.
and Espehaug, B.
and Midthjell, K.
and Graue, M.
and Rokne, B.
and Berge, L. I.
and Ostbye, T.",
title="Is depression a risk factor for diabetic foot ulcers?: 11-years follow-up of the Nord-Trondelag Health Study (HUNT)",
journal="J Diabetes Complications",
year="2015",
address="Faculty of Health and Social Sciences, Bergen University College, PO Box 7030, N-5020 Bergen, Norway",
volume="29",
number="1",
pages="20--25",
optkeywords="HUNT2; HUNT3; Age Distribution; Cohort Studies; Confidence Intervals; Depression/diagnosis/*epidemiology; Diabetic Foot/*epidemiology/physiopathology/*psychology/therapy; Female; Follow-Up Studies; Humans; Incidence; Logistic Models; Longitudinal Studies; Male; Neuropsychological Tests; Norway; Odds Ratio; *Quality of Life; Retrospective Studies; Risk Assessment; Severity of Illness Index; Sex Distribution; Time Factors; Wound Healing/physiology",
abstract="AIM: To prospectively examine whether depressive symptoms increase the risk of diabetes and a diabetic foot ulcer. METHODS: The Nord-Trondelag Health Study (HUNT) is a community-based longitudinal study. The Hospital Anxiety and Depression Scale (HADS-D subscale) assessed depressive symptoms. We followed individuals with complete HADS-D data from HUNT2 (1995-97) and assessed whether they reported diabetes with or without a history of diabetic foot ulcer (DFU) in HUNT3 (2006-08) (n=36,031). Logistic regression was used to investigate the effect of depressive symptoms on subsequent development of diabetes and of DFU. RESULTS: Unadjusted odds for reporting diabetes at follow-up was higher among individuals who reported a HADS-D score>/=8 at baseline (OR 1.30 95{\%} CI, 1.07-1.57) than among those reporting a lower score. After adjusting for age, gender and BMI, this association was no longer significant. The odds of developing a DFU was almost two-fold (OR=1.95 95{\%} CI, 1.02-3.74) for those reporting a HADS-D score of 8-10, and 3-fold (OR=3.06 95{\%} CI, 1.24-7.54) for HADS-D scores>/=11, compared to HADS-D scores",
optnote="exported from refbase (http://vev.medisin.ntnu.no/refbase/show.php?record=1826), last updated on Thu, 11 Aug 2016 12:42:25 +0200"
}