%0 Journal Article
%T Prolonged sitting may increase diabetes risk in physically inactive individuals: an 11 year follow-up of the HUNT Study, Norway
%A Asvold, B. O.
%A Midthjell, K.
%A Krokstad, S.
%A Rangul, V.
%A Bauman, A.
%J Diabetologia
%D 2017
%V 60
%N 5
%@ 0012-186X
%G English
%F Asvold_etal2017
%O PMID:28054097
%O exported from refbase (http://vev.medisin.ntnu.no/refbase/show.php?record=1879), last updated on Thu, 16 Nov 2017 21:49:27 +0100
%X AIMS/HYPOTHESIS: We examined the association between sitting time and diabetes incidence, overall and by strata of leisure-time physical activity and BMI. METHODS: We followed 28,051 adult participants of the Nord-Trondelag Health Study (the HUNT Study), a population-based study, for diabetes incidence from 1995-1997 to 2006-2008 and estimated HRs of any diabetes by categories of self-reported total daily sitting time at baseline. RESULTS: Of 28,051 participants, 1253 (4.5%) developed diabetes during 11 years of follow-up. Overall, sitting >/=8 h/day was associated with a 17% (95% CI 2, 34) higher risk of developing diabetes compared with sitting </=4 h/day, adjusted for age, sex and education. However, the association was attenuated to a non-significant 9% (95% CI -5, 26) increase in risk after adjustment for leisure-time physical activity and BMI. The association between sitting time and diabetes risk differed by leisure-time physical activity (p Interaction = 0.01). Among participants with low leisure-time physical activity (</=2 h light activity per week and no vigorous activity), sitting 5-7 h/day and >/=8 h/day were associated with a 26% (95% CI 2, 57) and 30% (95% CI 5, 61) higher risk of diabetes, respectively, compared with sitting </=4 h/day. There was no corresponding association among participants with high leisure-time physical activity (>/=3 h light activity or >0 h vigorous activity per week). There was no statistical evidence that the association between sitting time and diabetes risk differed by obesity (p Interaction = 0.65). CONCLUSIONS/INTERPRETATION: Our findings suggest that total sitting time has little association with diabetes risk in the population as a whole, but prolonged sitting may contribute to an increased diabetes risk among physically inactive people.
%K Adult
%K Body Mass Index
%K Diabetes Mellitus
%K Type 2/*epidemiology/metabolism
%K Exercise/physiology
%K Female
%K Humans
%K Incidence
%K Leisure Activities
%K Male
%K Middle Aged
%K *Sedentary Lifestyle
%K Epidemiology
%K Sedentary lifestyle
%K Type 2 diabetes mellitus
%R 10.1007/s00125-016-4193-z
%U http://www.ncbi.nlm.nih.gov/pubmed/28054097
%U https://doi.org/10.1007/s00125-016-4193-z
%P 830-835