TY  - JOUR
AU  - Borte, S.
AU  - Winsvold, B. S.
AU  - Stensland, S. O.
AU  - Smastuen, M. C.
AU  - Zwart, J-A
PY  - 2017
DA  - 2017//
TI  - The effect of foetal growth restriction on the development of migraine and tension-type headache in adulthood. The HUNT Study
T2  - PLoS One
JO  - PloS one
SP  - e0175908
VL  - 12
IS  - 4
KW  - Adult
KW  - Birth Weight
KW  - Female
KW  - Fetal Growth Retardation/epidemiology/*etiology
KW  - Gestational Age
KW  - Health Surveys
KW  - Humans
KW  - Infant
KW  - Newborn
KW  - Logistic Models
KW  - Male
KW  - Migraine Disorders/complications/*diagnosis/epidemiology
KW  - Norway/epidemiology
KW  - Odds Ratio
KW  - Pregnancy
KW  - Registries
KW  - Risk Factors
KW  - Tension-Type Headache/complications/*diagnosis/epidemiology
KW  - Young Adult
AB  - BACKGROUND: There is little knowledge about how factors early in life affect the development of migraine and tension-type headache. We aimed to examine whether growth restriction in utero is associated with development of migraine and frequent tension-type headache in adults. METHODS: The population-based Nord-Trondelag Health Study (HUNT 3) contained a validated headache questionnaire, which differentiated between migraine and tension-type headache. These data were linked to information on weight and gestational age at birth from the Norwegian Medical Birth Registry. In total 4557 females and 2789 males, aged 19-41 years, were included in this registry-based study. Participants were categorized as appropriate for gestational age (AGA, 10th-90th percentile), small for gestational age (SGA, 3rd-10th percentile) or very small for gestational age (VSGA, < 3rd percentile). Logistic regression was used to calculate odds ratios (OR) with 95% confidence intervals (CI) for migraine and tension-type headache, with exposure being growth restriction at birth. RESULTS: The effect of growth restriction on migraine was modified by sex, with a significant association in males (p<0.001), but not in females (p = 0.20). In particular, males born VSGA were at increased risk of developing migraine (OR 2.73, 95% CI 1.63-4.58, p<0.001), with an intermediate risk among those born SGA (OR 1.50, 95% CI 0.96-2.35, p = 0.08) compared to those born AGA. There was no significant association between growth restriction and frequent TTH (p = 0.051). CONCLUSION: Growth restriction was associated with increased risk of migraine in adulthood among males, but not among females. This suggests that migraine might, in part, be influenced by early life events, and that males seem to be particularly vulnerable.
SN  - 1932-6203
UR  - http://www.ncbi.nlm.nih.gov/pubmed/28410431
UR  - https://doi.org/10.1371/journal.pone.0175908
DO  - 10.1371/journal.pone.0175908
LA  - English
N1  - PMID:28410431; PMCID:PMC5391957
ID  - Borte_etal2017
ER  -