TY  - JOUR
AU  - Cai, Y.
AU  - Hansell, A. L.
AU  - Blangiardo, M.
AU  - Burton, P. R.
AU  - de Hoogh, K.
AU  - Doiron, D.
AU  - Fortier, I.
AU  - Gulliver, J.
AU  - Hveem, K.
AU  - Mbatchou, S.
AU  - Morley, D. W.
AU  - Stolk, R. P.
AU  - Zijlema, W. L.
AU  - Elliott, P.
AU  - Hodgson, S.
A2  - BioSHaRE
PY  - 2017
DA  - 2017//
TI  - Long-term exposure to road traffic noise, ambient air pollution, and cardiovascular risk factors in the HUNT and lifelines cohorts
T2  - Eur Heart J
JO  - European Heart Journal
SP  - 2290
EP  - 2296
VL  - 38
IS  - 29
KW  - Air pollution
KW  - Blood glucose
KW  - Blood lipids
KW  - Systemic inflammation
KW  - Traffic noise
AB  - Aims: Blood biochemistry may provide information on associations between road traffic noise, air pollution, and cardiovascular disease risk. We evaluated this in two large European cohorts (HUNT3, Lifelines). Methods and results: Road traffic noise exposure was modelled for 2009 using a simplified version of the Common Noise Assessment Methods in Europe (CNOSSOS-EU). Annual ambient air pollution (PM10, NO2) at residence was estimated for 2007 using a Land Use Regression model. The statistical platform DataSHIELD was used to pool data from 144 082 participants aged >/=20 years to enable individual-level analysis. Generalized linear models were fitted to assess cross-sectional associations between pollutants and high-sensitivity C-reactive protein (hsCRP), blood lipids and for (Lifelines only) fasting blood glucose, for samples taken during recruitment in 2006-2013. Pooling both cohorts, an inter-quartile range (IQR) higher day-time noise (5.1 dB(A)) was associated with 1.1% [95% confidence interval (95% CI: 0.02-2.2%)] higher hsCRP, 0.7% (95% CI: 0.3-1.1%) higher triglycerides, and 0.5% (95% CI: 0.3-0.7%) higher high-density lipoprotein (HDL); only the association with HDL was robust to adjustment for air pollution. An IQR higher PM10 (2.0 microg/m3) or NO2 (7.4 microg/m3) was associated with higher triglycerides (1.9%, 95% CI: 1.5-2.4% and 2.2%, 95% CI: 1.6-2.7%), independent of adjustment for noise. Additionally for NO2, a significant association with hsCRP (1.9%, 95% CI: 0.5-3.3%) was seen. In Lifelines, an IQR higher noise (4.2 dB(A)) and PM10 (2.4 microg/m3) was associated with 0.2% (95% CI: 0.1-0.3%) and 0.6% (95% CI: 0.4-0.7%) higher fasting glucose respectively, with both remaining robust to adjustment for air/noise pollution. Conclusion: Long-term exposures to road traffic noise and ambient air pollution were associated with blood biochemistry, providing a possible link between road traffic noise/air pollution and cardio-metabolic disease risk.
SN  - 0195-668X
UR  - http://www.ncbi.nlm.nih.gov/pubmed/28575405
UR  - https://doi.org/10.1093/eurheartj/ehx263
DO  - 10.1093/eurheartj/ehx263
LA  - English
N1  - PMID:28575405
ID  - Cai_etal2017
ER  -