TY  - JOUR
AU  - Gemes, K.
AU  - Malmo, V.
AU  - Laugsand, L. E.
AU  - Loennechen, J. P.
AU  - Ellekjaer, H.
AU  - Laszlo, K. D.
AU  - Ahnve, S.
AU  - Vatten, L. J.
AU  - Mukamal, K. J.
AU  - Janszky, I.
PY  - 2017
DA  - 2017//
TI  - Does Moderate Drinking Increase the Risk of Atrial Fibrillation? The Norwegian HUNT (Nord-Trondelag Health) Study
T2  - J Am Heart Assoc
JO  - Journal of the American Heart Association
VL  - 6
IS  - 10
KW  - Hunt
KW  - alcohol
KW  - atrial fibrillation
KW  - cohort study
KW  - epidemiology
KW  - moderate alcohol
AB  - BACKGROUND: Compelling evidence suggests that excessive alcohol consumption increases the risk of atrial fibrillation (AF), but the effect of light-moderate alcohol consumption is less certain. We investigated the association between alcohol consumption within recommended limits and AF risk in a light-drinking population. METHODS AND RESULTS: Among 47 002 participants with information on alcohol consumption in a population-based cohort study in Norway, conducted from October 2006 to June 2008, 1697 validated AF diagnoses were registered during the 8 years of follow-up. We used Cox proportional hazard models with fractional polynomials to analyze the association between alcohol intake and AF. Population attributable risk for drinking within the recommended limit (ie, at most 1 drink per day for women and 2 drinks per day for men without risky drinking) compared with nondrinking was also calculated. The average alcohol intake was 3.8+/-4.8 g/d. The adjusted hazard ratio for AF was 1.38 (95% confidence interval, 1.06-1.80) when we compared participants consuming >7 drinks per week with abstainers. When we modeled the quantity of alcohol intake as a continuous variable, the risk increased in a curvilinear manner. It was higher with heavier alcohol intake, but there was virtually no association at <1 drink per day for women and <2 drinks per day for men in the absence of risky drinking. The population attributable risk among nonrisky drinkers was 0.07% (95% confidence interval, -0.01% to 0.13%). CONCLUSIONS: Although alcohol consumption was associated with a curvilinearly increasing risk of AF in general, the attributable risk of alcohol consumption within recommended limits among participants without binge or problem drinking was negligible in this population.
SN  - 2047-9980
UR  - http://www.ncbi.nlm.nih.gov/pubmed/29054845
UR  - https://doi.org/10.1161/JAHA.117.007094
DO  - 10.1161/JAHA.117.007094
LA  - English
N1  - PMID:29054845; PMCID:PMC5721892
ID  - Gemes_etal2017
ER  -