@Article{Hellevik_etal2017,
author="Hellevik, A. I.
and Nordsletten, L.
and Johnsen, M. B.
and Fenstad, A. M.
and Furnes, O.
and Storheim, K.
and Zwart, J. A.
and Flugsrud, G.
and Langhammer, A.",
title="Age of menarche is associated with knee joint replacement due to primary osteoarthritis (The HUNT Study and the Norwegian Arthroplasty Register)",
journal="Osteoarthritis and Cartilage",
year="2017",
volume="25",
number="10",
pages="1654--1662",
optkeywords="Hip joint replacement; Hormonal therapies; Knee joint replacement; Osteoarthritis; Reproductive history",
abstract="OBJECTIVE: To investigate whether parity, age at menarche, menopausal status, age at menopause, use of oral contraceptives (OC) or use of hormone replacement therapy (HRT) were associated with total knee replacement (TKR) or total hip replacement (THR) due to primary osteoarthritis. METHOD: In a prospective cohort study of 30,289 women from the second and third surveys of the Nord-Trondelag Health Study, data were linked to the Norwegian Arthroplasty Register (NAR) in order to identify TKR or THR due to primary osteoarthritis. Cox proportional hazards models were used to estimate the hazard ratios (HRs). RESULTS: We observed 430 TKRs and 675 THRs during a mean follow-up time of 8.3 years. Increasing age at menarche was inversely associated with the risk of TKR (P-trend < 0.001). Past users and users of systemic HRT were at higher risk of TKR compared to never users (HR 1.42 (95{\%} confidence interval (CI) 1.06-1.90) and HR 1.40 (95{\%} CI 1.03-1.90), respectively). No association was found between parity, age at menarche, menopausal status, age at menopause, oral contraceptive use or HRT use and THR. CONCLUSION: We found that increasing age at menarche reduced the risk of TKR. Past users and users of systemic HRT were at higher risk of TKR compared to never users. Parity did not increase the risk of THR or TKR.",
optnote="PMID:28705605",
optnote="exported from refbase (http://vev.medisin.ntnu.no/refbase/show.php?record=1925), last updated on Fri, 02 Feb 2018 16:04:38 +0100",
issn="1063-4584",
doi="10.1016/j.joca.2017.06.010",
opturl="http://www.ncbi.nlm.nih.gov/pubmed/28705605",
opturl="https://doi.org/10.1016/j.joca.2017.06.010",
language="English"
}