TY  - JOUR
AU  - Hellevik, A. I.
AU  - Nordsletten, L.
AU  - Johnsen, M. B.
AU  - Fenstad, A. M.
AU  - Furnes, O.
AU  - Storheim, K.
AU  - Zwart, J. A.
AU  - Flugsrud, G.
AU  - Langhammer, A.
PY  - 2017
DA  - 2017//
TI  - Age of menarche is associated with knee joint replacement due to primary osteoarthritis (The HUNT Study and the Norwegian Arthroplasty Register)
T2  - Osteoarthritis Cartilage
JO  - Osteoarthritis and Cartilage
SP  - 1654
EP  - 1662
VL  - 25
IS  - 10
KW  - Hip joint replacement
KW  - Hormonal therapies
KW  - Knee joint replacement
KW  - Osteoarthritis
KW  - Reproductive history
AB  - OBJECTIVE: To investigate whether parity, age at menarche, menopausal status, age at menopause, use of oral contraceptives (OC) or use of hormone replacement therapy (HRT) were associated with total knee replacement (TKR) or total hip replacement (THR) due to primary osteoarthritis. METHOD: In a prospective cohort study of 30,289 women from the second and third surveys of the Nord-Trondelag Health Study, data were linked to the Norwegian Arthroplasty Register (NAR) in order to identify TKR or THR due to primary osteoarthritis. Cox proportional hazards models were used to estimate the hazard ratios (HRs). RESULTS: We observed 430 TKRs and 675 THRs during a mean follow-up time of 8.3 years. Increasing age at menarche was inversely associated with the risk of TKR (P-trend < 0.001). Past users and users of systemic HRT were at higher risk of TKR compared to never users (HR 1.42 (95% confidence interval (CI) 1.06-1.90) and HR 1.40 (95% CI 1.03-1.90), respectively). No association was found between parity, age at menarche, menopausal status, age at menopause, oral contraceptive use or HRT use and THR. CONCLUSION: We found that increasing age at menarche reduced the risk of TKR. Past users and users of systemic HRT were at higher risk of TKR compared to never users. Parity did not increase the risk of THR or TKR.
SN  - 1063-4584
UR  - http://www.ncbi.nlm.nih.gov/pubmed/28705605
UR  - https://doi.org/10.1016/j.joca.2017.06.010
DO  - 10.1016/j.joca.2017.06.010
LA  - English
N1  - PMID:28705605
ID  - Hellevik_etal2017
ER  -