%0 Journal Article
%T Psoriasis, fracture risk and bone mineral density: the HUNT Study, Norway
%A Modalsli, E. H.
%A Asvold, B. O.
%A Romundstad, P. R.
%A Langhammer, A.
%A Hoff, M.
%A Forsmo, S.
%A Naldi, L.
%A Saunes, M.
%J The British Journal of Dermatology
%D 2017
%V 176
%N 5
%@ 0007-0963
%G English
%F Modalsli_etal2017
%O PMID:27718508
%O exported from refbase (http://vev.medisin.ntnu.no/refbase/show.php?record=1955), last updated on Fri, 02 Feb 2018 16:09:14 +0100
%X BACKGROUND: An association between psoriasis and osteoporosis has been reported. OBJECTIVES: To investigate, in a large prospective population-based Norwegian study, whether psoriasis is associated with increased risk of forearm or hip fracture; to investigate the cross-sectional association between psoriasis and bone mineral density (BMD) T-score in a subpopulation. METHODS: Hospital-derived fracture data from Nord-Trondelag County (1995-2013) were linked to psoriasis information, BMD measurements and lifestyle factors from the third survey of the Nord-Trondelag Health Study 2006-08 (HUNT3); socioeconomic data from the National Education Database; and use of medication from the Norwegian Prescription Database. RESULTS: Among 48 194 participants in HUNT3, we found no increased risk of forearm or hip fracture in 2804 patients with self-reported psoriasis [overall age- and sex-adjusted hazard ratio 1.03, 95% confidence interval (CI) 0.82-1.31]. No clear association was found between psoriasis and mean BMD T-score; overall age- and sex-adjusted differences in total hip, femoral neck and lumbar spine BMD T-scores were 0.02 (95% CI -0.11 to 0.14), 0.05 (95% CI -0.06 to 0.17) and 0.07 (95% CI -0.09 to 0.24), respectively. No clear association was found between psoriasis and prevalent osteoporosis in either total hip, femoral neck or lumbar spine; overall age- and sex-adjusted odds ratio was 0.77 (95% CI 0.54-1.10). Associations did not change substantially after adjustment for education, smoking, systemic steroid use and body mass index. CONCLUSIONS: We found no association between psoriasis and risk of fracture. The study did not indicate reduced BMD T-score or higher prevalence of osteoporosis among patients with psoriasis.
%R 10.1111/bjd.15123
%U http://www.ncbi.nlm.nih.gov/pubmed/27718508
%U https://doi.org/10.1111/bjd.15123
%P 1162-1169