TY  - JOUR
AU  - Modalsli, E. H.
AU  - Asvold, B. O.
AU  - Romundstad, P. R.
AU  - Langhammer, A.
AU  - Hoff, M.
AU  - Forsmo, S.
AU  - Naldi, L.
AU  - Saunes, M.
PY  - 2017
DA  - 2017//
TI  - Psoriasis, fracture risk and bone mineral density: the HUNT Study, Norway
T2  - Br J Dermatol
JO  - The British Journal of Dermatology
SP  - 1162
EP  - 1169
VL  - 176
IS  - 5
AB  - BACKGROUND: An association between psoriasis and osteoporosis has been reported. OBJECTIVES: To investigate, in a large prospective population-based Norwegian study, whether psoriasis is associated with increased risk of forearm or hip fracture; to investigate the cross-sectional association between psoriasis and bone mineral density (BMD) T-score in a subpopulation. METHODS: Hospital-derived fracture data from Nord-Trondelag County (1995-2013) were linked to psoriasis information, BMD measurements and lifestyle factors from the third survey of the Nord-Trondelag Health Study 2006-08 (HUNT3); socioeconomic data from the National Education Database; and use of medication from the Norwegian Prescription Database. RESULTS: Among 48 194 participants in HUNT3, we found no increased risk of forearm or hip fracture in 2804 patients with self-reported psoriasis [overall age- and sex-adjusted hazard ratio 1.03, 95% confidence interval (CI) 0.82-1.31]. No clear association was found between psoriasis and mean BMD T-score; overall age- and sex-adjusted differences in total hip, femoral neck and lumbar spine BMD T-scores were 0.02 (95% CI -0.11 to 0.14), 0.05 (95% CI -0.06 to 0.17) and 0.07 (95% CI -0.09 to 0.24), respectively. No clear association was found between psoriasis and prevalent osteoporosis in either total hip, femoral neck or lumbar spine; overall age- and sex-adjusted odds ratio was 0.77 (95% CI 0.54-1.10). Associations did not change substantially after adjustment for education, smoking, systemic steroid use and body mass index. CONCLUSIONS: We found no association between psoriasis and risk of fracture. The study did not indicate reduced BMD T-score or higher prevalence of osteoporosis among patients with psoriasis.
SN  - 0007-0963
UR  - http://www.ncbi.nlm.nih.gov/pubmed/27718508
UR  - https://doi.org/10.1111/bjd.15123
DO  - 10.1111/bjd.15123
LA  - English
N1  - PMID:27718508
ID  - Modalsli_etal2017
ER  -