@Article{Paulsen_etal2017,
author="Paulsen, J.
and Askim, A.
and Mohus, R. M.
and Mehl, A.
and Dewan, A.
and Solligard, E.
and Damas, J. K.
and Asvold, B. O.",
title="Associations of obesity and lifestyle with the risk and mortality of bloodstream infection in a general population: a 15-year follow-up of 64 027 individuals in the HUNT Study",
journal="International Journal of Epidemiology",
year="2017",
volume="46",
number="5",
pages="1573--1581",
optkeywords="Bacteraemia; alcohol drinking; exercise; obesity; sepsis; smoking",
abstract="Background: Bloodstream infections (BSI) cause considerable morbidity and mortality, and primary prevention should be a priority. Lifestyle factors are of particular interest since they represent a modifiable target. Methods: We conducted a prospective cohort study among participants in the population-based Norwegian HUNT2 Survey, where 64 027 participants were followed from 1995-97 through 2011 by linkage to prospectively recorded information on BSI at local and regional hospitals. The exposures were: baseline body mass index (BMI) measurements; and self-reported smoking habits, leisure time physical activity and alcohol intake. The outcomes were hazard ratios (HR) of BSI and BSI mortality. Results: During 810 453 person-years and median follow-up of 14.8 years, 1844 (2.9{\%}) participants experienced at least one BSI and 396 (0.62{\%}) died from BSI. Compared with normal weight participants (BMI 18.5-24.9 kg/m2), the age- and sex-adjusted risk of a first-time BSI was 31{\%} [95{\%} confidence interval (CI) 14-51{\%}] higher at BMI 30.0-34.9 kg/m2, 87{\%} (95{\%} CI 50-135{\%}) higher at BMI 35.0-39.9 kg/m2 and 210{\%} (95{\%} CI 117-341{\%}) higher at BMI >/= 40.0 kg/m2. The risk of BSI mortality was similarly increased. Compared with never-smokers, current smokers had 51{\%} (95{\%} CI 34-70{\%}) and 75{\%} (95{\%} CI 34-129{\%}) higher risks of BSI and BSI mortality, respectively. Physically inactive participants had 71{\%} (95{\%} CI 42-107{\%}) and 108{\%} (95{\%} CI 37-216{\%}) higher risks of BSI and BSI mortality, respectively, compared with the most physically active. Conclusions: Obesity, smoking and physical inactivity carry increased risk of BSI and BSI mortality.",
optnote="PMID:28637260",
optnote="exported from refbase (http://vev.medisin.ntnu.no/refbase/show.php?record=1969), last updated on Fri, 02 Feb 2018 16:12:27 +0100",
issn="0300-5771",
doi="10.1093/ije/dyx091",
opturl="http://www.ncbi.nlm.nih.gov/pubmed/28637260",
opturl="https://doi.org/10.1093/ije/dyx091",
language="English"
}