@Article{Perreault_etal2017,
author="Perreault, K.
and Bauman, A.
and Johnson, N.
and Britton, A.
and Rangul, V.
and Stamatakis, E.",
title="Does physical activity moderate the association between alcohol drinking and all-cause, cancer and cardiovascular diseases mortality? A pooled analysis of eight British population cohorts",
journal="British Journal of Sports Medicine",
year="2017",
volume="51",
number="8",
pages="651--657",
optkeywords="Adult; Aged; 80 and over; Alcohol Drinking/*adverse effects; Cardiovascular Diseases/*mortality; England; *Exercise; Female; Health Surveys; Humans; Male; Middle Aged; Mortality; Neoplasms/*mortality; Proportional Hazards Models; Prospective Studies; Risk Factors; Cancer; Epidemiology; Physical activity; Public health",
abstract="OBJECTIVE: To examine whether physical activity (PA) moderates the association between alcohol intake and all-cause mortality, cancer mortality and cardiovascular diseases (CVDs) mortality. DESIGN: Prospective study using 8 British population-based surveys, each linked to cause-specific mortality: Health Survey for England (1994, 1998, 1999, 2003, 2004 and 2006) and Scottish Health Survey (1998 and 2003). PARTICIPANTS: 36 370 men and women aged 40 years and over were included with a corresponding 5735 deaths and a mean of 353 049 person-years of follow-up. EXPOSURES: 6 sex-specific categories of alcohol intake (UK units/week) were defined: (1) never drunk; (2) ex-drinkers; (3) occasional drinkers; (4) within guidelines (<14 (women); <21 (men)); (5) hazardous (14-35 (women); 21-49 (men)) and (6) harmful (>35 (women) >49 (men)). PA was categorised as inactive (</=7 MET-hour/week), active at the lower (>7.5 MET-hour/week) and upper (>15 MET-hour/week) of recommended levels. MAIN OUTCOMES AND MEASURES: Cox proportional-hazard models were used to examine associations between alcohol consumption and all-cause, cancer and CVD mortality risk after adjusting for several confounders. Stratified analyses were performed to evaluate mortality risks within each PA stratum. RESULTS: We found a direct association between alcohol consumption and cancer mortality risk starting from drinking within guidelines (HR (95{\%} CI) hazardous drinking: 1.40 (1.11 to 1.78)). Stratified analyses showed that the association between alcohol intake and mortality risk was attenuated (all-cause) or nearly nullified (cancer) among individuals who met the PA recommendations (HR (95{\%} CI)). CONCLUSIONS: Meeting the current PA public health recommendations offsets some of the cancer and all-cause mortality risk associated with alcohol drinking.",
optnote="PMID:27581162",
optnote="exported from refbase (http://vev.medisin.ntnu.no/refbase/show.php?record=1970), last updated on Fri, 02 Feb 2018 16:12:27 +0100",
issn="0306-3674",
doi="10.1136/bjsports-2016-096194",
opturl="http://www.ncbi.nlm.nih.gov/pubmed/27581162",
opturl="https://doi.org/10.1136/bjsports-2016-096194",
language="English"
}