@Article{Snekvik_etal2017,
author="Snekvik, I.
and Smith, C. H.
and Nilsen, T. I. L.
and Langan, S. M.
and Modalsli, E. H.
and Romundstad, P. R.
and Saunes, M.",
title="Obesity, Waist Circumference, Weight Change, and Risk of Incident Psoriasis: Prospective Data from the HUNT Study",
journal="The Journal of Investigative Dermatology",
year="2017",
volume="137",
number="12",
pages="2484--2490",
optkeywords="Adult; Body Mass Index; Body Weight; Female; Humans; Male; Middle Aged; Norway; Obesity/*diagnosis/epidemiology; Proportional Hazards Models; Prospective Studies; Psoriasis/complications/*diagnosis/*epidemiology; Risk Factors; *Waist Circumference; Waist-Hip Ratio",
abstract="Although psoriasis has been associated with obesity, there are few prospective studies with objective measures. We prospectively examined the effect of body mass index, waist circumference, waist-hip ratio, and 10-year weight change on the risk of developing psoriasis among 33,734 people in the population-based Nord-Trondelag Health Study (i.e., HUNT), Norway. During follow-up, 369 incident psoriasis cases occurred. Relative risk (RR) of psoriasis was estimated by Cox regression. One standard deviation higher body mass index, waist circumference, and waist-hip ratio gave RRs of 1.22 (95{\%} confidence interval [CI] = 1.11-1.34), 1.26 (95{\%} CI = 1.15-1.39), and 1.18 (95{\%} CI = 1.07-1.31), respectively. Compared with normal weight participants, obese people had an RR of 1.87 (95{\%} CI = 1.38-2.52), whereas comparing the fourth with the first quartile of waist circumference gave an RR of 1.95 (95{\%} CI = 1.46-2.61). One standard deviation higher weight change gave an RR of 1.20 (95{\%} CI = 1.07-1.35), and people who increased their body weight by 10 kg or more had an RR of 1.72 (95{\%} CI = 1.15-2.58) compared with being weight stable. In conclusion, obesity and high abdominal fat mass doubles the risk of psoriasis, and long-term weight gain substantially increases psoriasis risk. Preventing weight gain and promoting maintenance of a normal body weight could reduce incidence of psoriasis.",
optnote="PMID:28780086",
optnote="exported from refbase (http://vev.medisin.ntnu.no/refbase/show.php?record=1988), last updated on Fri, 02 Feb 2018 16:15:10 +0100",
issn="0022-202X",
doi="10.1016/j.jid.2017.07.822",
opturl="http://www.ncbi.nlm.nih.gov/pubmed/28780086",
opturl="https://doi.org/10.1016/j.jid.2017.07.822",
language="English"
}