%0 Journal Article
%T Monocyte/macrophage and T cell activation markers are not independently associated with MI risk in healthy individuals – results from the HUNT Study
%A Ueland, T.
%A Laugsand, L. E.
%A Vatten, L. J.
%A Janszky, I.
%A Platou, C.
%A Michelsen, A. E.
%A Damas, J. K.
%A Aukrust, P.
%A Asvold, B. O.
%J International Journal of Cardiology
%D 2017
%V 243
%@ 0167-5273
%G English
%F Ueland_etal2017
%O PMID:28615143
%O exported from refbase (http://vev.medisin.ntnu.no/refbase/show.php?record=2016), last updated on Fri, 02 Feb 2018 16:17:28 +0100
%X BACKGROUND: We hypothesized that circulating markers reflecting monocyte/macrophage and T cell activation are associated with increased risk of myocardial infarction (MI) in apparently healthy individuals. METHODS: Serum monocyte/macrophage and T cell activation markers soluble (s) CD163, sCD14, Gal3BP, sCD25 and sCD166 were analyzed by enzyme-immunoassay in a case-control study nested within the population-based HUNT2 cohort in Norway. Among 58,761 apparently healthy men and women followed a median 11.3years, 1587 incident MI cases were registered, and compared to 3959 age- and sex-matched controls. RESULTS: Higher serum sCD163 (Q4 vs. Q1 OR: 1.27, P-trend 0.002), sCD14 (Q4 vs. Q1 OR: 1.38, P-trend<0.001), and especially sCD25 (Q4 vs. Q1 OR: 1.45, P-trend<0.001), were associated with increased MI risk in the age-and sex adjusted models. However, after additional adjustment for cardiovascular risk factors these associations were strongly attenuated (Q4 vs Q1 ORs between 1.02 and 1.12, P-trends between 0.30 and 0.58). CONCLUSIONS: sCD163, sCD14 and sCD25 may reflect leukocyte activation and inflammatory mechanisms related to atherogenesis, but do not predict MI risk above and beyond conventional cardiovascular risk factors.
%K Leukocyte markers
%K Myocardial infarction
%R 10.1016/j.ijcard.2017.05.106
%U http://www.ncbi.nlm.nih.gov/pubmed/28615143
%U https://doi.org/10.1016/j.ijcard.2017.05.106
%P 502-504